LGALS3

Understanding Entity Pages

This page aggregates everything SciDEX knows about LGALS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

LGALS3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 455 entities in the SciDEX knowledge graph.

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graph TD
    LGALS3["<b>LGALS3</b><br/>(Galectin-3)""]:::central
    
    LGALS3 -->|"interacts_with"| Dementia["Dementia"]
    LGALS3 -->|"interacts_with"| Cardiovascular["Cardiovascular<br/>Disease"]
    LGALS3 -->|"interacts_with"| Als["ALS"]
    LGALS3 -->|"interacts_with"| Alzheimer["Alzheimer's<br/>Disease"]
    LGALS3 -->|"interacts_with"| Parkinson["Parkinson's<br/>Disease"]
    LGALS3 -->|"interacts_with"| Ms["Multiple<br/>Sclerosis"]
    LGALS3 -->|"associated_with"| AmyotrophicLateralSclerosis["Amyotrophic<br/>Lateral Sclerosis"]
    LGALS3 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    LGALS3 -->|"associated_with"| Ataxia["Ataxia"]
    LGALS3 -->|"associated_with"| Huntington["Huntington's<br/>Disease"]
    LGALS3 -->|"therapeutic_target"| AlsTarget["ALS<br/>Treatment"]
    LGALS3 -->|"therapeutic_target"| MsTarget["MS<br/>Treatment"]
    
    classDef central fill:#FF6B6B,stroke:#C92A2A,stroke-width:3px,color:#e0e0e0,font-size:14px
    classDef disease fill:#4ECDC4,stroke:#0A8A80,stroke-width:2px,color:#e0e0e0
    classDef process fill:#FFE66D,stroke:#D4A600,stroke-width:2px,color:#e0e0e0
    classDef target fill:#95E1D3,stroke:#38A169,stroke-width:2px,color:#e0e0e0
    
    class Dementia,Cardiovascular,Als,Alzheimer,Parkinson,Ms,AmyotrophicLateralSclerosis,Ataxia,Huntington disease
    class Neurodegeneration process
    class AlsTarget,MsTarget target