concept

WHITE MATTER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WHITE MATTER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

605Connections

14Hypotheses

1Analyses

50Outgoing

50Incoming

4Experiments

1Debates

Summary

WHITE MATTER is a concept in neurodegeneration research. Key relationships include: co discussed, activates, causes. Associated with ALS, ANXIETY, DEMENTIA. Connected to 36 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	WHITE MATTER
Key Genes/Proteins	ABI3, AKT, AMPK, AMYLOID, APOE, APOE4
Related Diseases	AGING, ALS, ALZHEIMER'S DISEASE, ANXIETY
Related Pathways	AMPK SIGNALING

Pathway Diagram

graph TD
    WHITE_MATTER["WHITE MATTER"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"expressed in"| WHITE_MATTER
    MYELIN["MYELIN"] -->|"expressed in"| WHITE_MATTER
    OLIGODENDROCYTE["OLIGODENDROCYTE"] -->|"expressed in"| WHITE_MATTER
    AQP4["AQP4"] -->|"expressed in"| WHITE_MATTER
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"expressed in"| WHITE_MATTER
    JAM2["JAM2"] -->|"expressed in"| WHITE_MATTER
    JUN["JUN"] -->|"expressed in"| WHITE_MATTER
    GENES["GENES"] -->|"expressed in"| WHITE_MATTER
    XPR1["XPR1"] -->|"expressed in"| WHITE_MATTER
    SLC20A2["SLC20A2"] -->|"expressed in"| WHITE_MATTER

Outgoing (117)

Target	Relation	Type	Str
aging brain vulnerability	associated_with	phenotype	0.70
PROTEIN AGGREGATION	stabilizes	phenotype	0.70
PROTEIN AGGREGATION	activates	phenotype	0.70
NEURON	stabilizes	cell_type	0.70
LIPID PEROXIDATION	causes	phenotype	0.70
NEURODEGENERATION	increases_risk	phenotype	0.70
APOE	treats	gene	0.70
APOE	stabilizes	gene	0.70
APOE	regulates	gene	0.70
ALS	treats	disease	0.70
NEUROINFLAMMATION	regulates	phenotype	0.65
PSEN1	interacts_with	gene	0.65
MICROGLIA	associated_with	cell_type	0.65
TREM2	regulates	gene	0.65
NECROPTOSIS	regulates	phenotype	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
ALZHEIMER'S DISEASE	regulates	disease	0.65
TRAUMATIC BRAIN INJURY	causes	disease	0.65
ALZHEIMER'S DISEASE	implicated_in	disease	0.60
FORNIX	stabilizes	brain_region	0.60
FORNIX	treats	brain_region	0.60
CORPUS CALLOSUM	treats	brain_region	0.60
TAU	targets	protein	0.60
REMYELINATION	inhibits	concept	0.50
GLUTAMATE	associated_with	concept	0.50
GLUTAMATE	inhibits	concept	0.50
ISCHEMIC	causes	concept	0.50
BRAINSTEM	associated_with	concept	0.50
NUCLEUS	expressed_in	concept	0.50
REMYELINATION	causes	concept	0.50
Cognitive Impairment	inhibits	phenotype	0.50
DEMYELINATION	activates	concept	0.50
CEREBRAL CORTEX	associated_with	concept	0.50
HDAC3	associated_with	gene	0.50
LACTATE	associated_with	phenotype	0.50
DEMYELINATION	causes	concept	0.50
GRAY MATTER	causes	concept	0.50
OLIGODENDROCYTES	associated_with	concept	0.50
OLIGODENDROCYTES	activates	concept	0.50
NEURODEGENERATIVE DISEASE	inhibits	concept	0.50
SENESCENCE	associated_with	phenotype	0.50
MTOR	associated_with	gene	0.50
PI3K	associated_with	gene	0.50
AKT	associated_with	gene	0.50
TNF	associated_with	gene	0.50
SYK	associated_with	gene	0.50
OLIG2	associated_with	gene	0.50
MBP	associated_with	gene	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
ISCHEMIC	associated_with	concept	0.50

Incoming (488)

Source	Relation	Type	Str
multiple sclerosis	affects	disease	0.90
Aging	causes	process	0.90
Microglia	associated_with	cell_type	0.88
Microglia Nodules	expressed_in	phenotype	0.88
TAU	associated_with	protein	0.85
aging	affects	disease	0.80
neurodegeneration	affects	disease	0.80
neuroinflammation	affects	disease	0.80
CYP46A1	activates	gene	0.70
ferroptosis	active_in	pathway	0.70
traumatic brain injury	affects	disease	0.70
AGING	stabilizes	phenotype	0.70
GRAY MATTER	treats	brain_region	0.70
ALS	stabilizes	disease	0.70
GRAY MATTER	stabilizes	brain_region	0.70
axon	enriched_in	organelle	0.70
MICROGLIAL ACTIVATION	treats	phenotype	0.70
AGING	treats	phenotype	0.70
OLIGODENDROCYTE	causes	cell_type	0.65
BASAL GANGLIA	activates	brain_region	0.65
OLIGODENDROCYTE	regulates	cell_type	0.65
OLIGODENDROCYTES	causes	cell_type	0.65
VEGFA	interacts_with	gene	0.65
CURCUMIN	treats	drug	0.65
GLUTAMATE	produces	phenotype	0.65
NRF2	regulates	gene	0.65
OLIGODENDROCYTES	activates	cell_type	0.65
CORTEX	phosphorylates	brain_region	0.65
TAU	phosphorylates	gene	0.65
TRAUMATIC BRAIN INJURY	contributes_to	disease	0.65
NRF2	activates	gene	0.65
STING	activates	gene	0.65
NRF2	promotes	gene	0.65
GLUTAMATE	transports	phenotype	0.65
MACROPHAGES	causes	cell_type	0.65
STROKE	protects_against	disease	0.65
PHAGOCYTOSIS	inhibits	phenotype	0.65
MICROGLIA	protects_against	cell_type	0.65
AGING	exacerbates	phenotype	0.65
GLUTAMATE	targets	phenotype	0.65
ISCHEMIC	causes	disease	0.65
NEURON	associated_with	cell_type	0.65
MICROGLIA	associated_with	cell_type	0.65
NEURON	expressed_in	cell_type	0.65
CHOLESTEROL	causes	phenotype	0.65
SMPD1	inhibits	gene	0.65
CHOLESTEROL	activates	phenotype	0.65
CORTEX	reduces	brain_region	0.65
ENTORHINAL	reduces	brain_region	0.65
HIPPOCAMPUS	expressed_in	brain_region	0.60

Targeting Hypotheses (14)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	alzheimers	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.779	alzheimers	Cell type vulnerability in Alzheimers Di
Oligodendrocyte Precursor Cell Senescence in White Matter Di	0.769	-	Senescent cell clearance as neurodegener
Metabolic Checkpoint Failure in NG2+ Oligodendrocyte Progeni	0.680	neurodegeneration	-
White Matter Oligodendrocyte Protection via CXCL10 Inhibitio	0.675	neurodegeneration	Gene expression changes in aging mouse b

White Matter Vulnerability Prevention via Oligodendrocyte Pr	0.667	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte White Matter Vulnerability	0.651	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling	0.649	neurodegeneration	Gene expression changes in aging mouse b
White Matter Immune Checkpoint Restoration	0.644	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White	0.600	neurodegeneration	Gene expression changes in aging mouse b
OPC differentiation blockade contributes to white matter deg	0.599	alzheimers	SEA-AD Single-Cell Analysis: Cell-Type V
TREM2-Mediated Oligodendrocyte-Microglia Signaling in White	0.587	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Oligodendrocyte Metabolic Support in White Ma	0.380	neurodegeneration	TREM2 in Alzheimer's Disease: Mechanisms
Oligodendrocyte Precursor Cell Senescence as Primary Driver	0.000	-	Senescent cell clearance as neurodegener

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 0 hypotheses

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	mouse models of Alzheimer's di	proposed	N/A
CXCL10 biomarker analysis for CPSP prediction	clinical	chronic postsurgical pain	0.900	human patients undergoing thor	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	human brain tissue	proposed	N/A
E2F coordination of G2/M transcriptional program	exploratory		0.750	endocycling mammalian cells	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular ma [PMID:41053177]	Lin B, Zhou J, Geng D, Chai S, Zhang X e	Cell Death Differ	2026
Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha [PMID:41077603]	Ye L, Zhao T, Tian H, Li R, Li Z et al.	Sci China Life Sci	2026
METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934]	Sun Y, Ren Z, Ge J, Zhang W, Shao F et a	Biochim Biophys Acta Mol Basis	2026
Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107]	Lan T, Shang D, Lin L, Wang H, Zou J et	Autophagy	2026
The mechanism of Qing-Fei-Yin decoction against influenza: Synergistical inhibit [PMID:41317805]	Nie W, Wang M, Cheng M, Ren Z, Liu G et	J Ethnopharmacol	2026
IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095]	Peng M, Shu D, Chen Z, Yang Z, Zhang M e	J Neuroinflammation	2026
Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814]	Zhang X, Xue J, Zhao C, Zeng C, Zhong J	J Clin Invest	2026
Overlapping autoimmunity and demyelination syndromes associated with TNF inhibit [PMID:41652144]	Daood R, Naffaa ME, Azrilin O, Hassan F,	Clin Rheumatol	2026
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028]	Yu D, Kang J, Jiang W, Zhang C, Zhao X e	Neuropharmacology	2026
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614]	Li Z, Tan B, Dong K, Yu X, Zhang SW et a	Biochem Pharmacol	2026
Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873]	Main BS, Villapol S, Buenaventura RG, Ha	Brain Behav Immun	2026
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781]	Bruna-Jara B, More J, Lobos P, Ponce DP,	Scientific reports	2026
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting [PMID:41799958]	Wu W, Cheng Z, Shi P, Gao H, Chen X et a	Bioact Mater	2026
Immune checkpoint inhibitor-associated inflammatory arthritis. [PMID:41800958]	Kim ST, Bass AR	Arthritis Rheumatol	2026
Genetic Variation in the Chemokine Network and Atherosclerosis Risk. [PMID:41824188]	Zangas P, Georgakis MK	Curr Atheroscler Rep	2026
Pathogenic mechanisms of action of autoantibody-mediated central nervous system [PMID:41831629]	Lerch M, Irani SR, Ramanathan S	Autoimmun Rev	2026
Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505]	Ghosh S, Li X, Rawat K, Dighal A, Kalino	Nat Immunol	2026
TRUE-MOGAD Score: A Novel Scoring System to Identify MOGAD Among Positive MOG-Ig [PMID:41921125]	Vilaseca A, Filippatou AG, Said Y, Sechi	Neurol Neuroimmunol Neuroinfla	2026
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. [PMID:41925507]	Flanagan EP, Hemingway C	Continuum (Minneap Minn)	2026
Therapeutic updates in NMOSD and MOGAD: From present practice to future promise. [PMID:41927387]	Elosua-Bayés I, Cobo-Calvo A	Rev Neurol (Paris)	2026

Debates (1)

Multi-agent debates referencing this entity

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning WHITE MATTER in their description or question text

WHITE MATTER

Understanding Entity Pages

Summary

Pathway Diagram

Outgoing (117)

Incoming (488)

Targeting Hypotheses (14)

Mentioning Analyses (1)

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Experiments (4)

Related Papers (20)

Debates (1)

What gene expression changes in the aging mouse brain predict neurodegenerative

Related Research

White Matter Vulnerability Prevention via Oligodendrocyte Protection

Oligodendrocyte White Matter Vulnerability

TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling in White Matter Neur

White Matter Immune Checkpoint Restoration

TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White Matter Neurodegener

OPC differentiation blockade contributes to white matter degeneration in early-s

TREM2-Mediated Oligodendrocyte-Microglia Signaling in White Matter Neurodegenera

TREM2-Mediated Oligodendrocyte Metabolic Support in White Matter Neurodegenerati

Oligodendrocyte Precursor Cell Senescence as Primary Driver of White Matter Dege