Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIRT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Deacetylation | catalyzes | process | 0.90 |
| Neurodegeneration | modulates | process | 0.90 |
| Genome Stability | regulates | process | 0.85 |
| Longevity | regulates | phenotype | 0.85 |
| NAD+ | degrades | chemical | 0.80 |
| Obesity | associated_with | disease | 0.80 |
| Diabetes | associated_with | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Calorie Restriction | activates | process | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc | 0.600 | neurodegeneration | Gene expression changes in aging mouse b |
| TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging | 0.587 | neurodegeneration | Gene expression changes in aging mouse b |
| SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK | 0.509 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression R | 0.498 | neuropharmacology | What determines blood-brain barrier pene |
| SIRT6-NAD+ Axis Enhancement Therapy | 0.395 | neurodegeneration | Epigenetic clocks and biological aging i |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966] | Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X | Theranostics | 2023 | 1 |
| Assessing the Status of Mandatory Tuberculosis Case Notification among Private P [PMID:35068738] | Duggal K, Elsy M, Majella MG, Akkilagunt | Indian J Community Med | 2021 | 1 |
| Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic [PMID:33888596] | Yoshino M, Yoshino J, Kayser BD, Patti G | Science | 2021 | 1 |
| Protocol for the Bottom-Up Proteomic Analysis of Mouse Spleen. [PMID:33377090] | Dowling P, Gargan S, Zweyer M, Henry M, | STAR Protoc | 2020 | 1 |
| Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity [PMID:30193097] | Latorre-Muro P, Baeza J, Armstrong EA, H | Mol Cell | 2018 | 1 |
| The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcin [PMID:28329682] | Nargund AM, Pham CG, Dong Y, Wang PI, Os | Cell Rep | 2017 | 1 |
| Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype [PMID:26686024] | Wiley CD, Velarde MC, Lecot P, Liu S, Sa | Cell Metab | 2016 | 1 |
| SIRT6 inhibits intermittent hypoxia-induced lung injury by stabilizing NRF2. [PMID:41478020] | Qin R, Liu Z, Li R, Li Y, Yang Y et al. | Tissue Cell | 2026 | 0 |
| Inflammation-targeted single-atom nanozymes drive microglial depolarization and [PMID:41624511] | Liu B, Xiang C, Zhang X, Guo W, Wu H et | Mater Today Bio | 2026 | 0 |
| Bupleurum chinense ameliorates metabolic-associated fatty liver disease by modul [PMID:41666508] | Liu S, Chen P, Li Y, Pan Z, Zhang C et a | Phytomedicine | 2026 | 0 |
| Deciphering the role of SIRT6 in suppressing the AMPK-mTOR-TFEB axis: regulation [PMID:41957523] | Li CS, Jin H, Meng R, Baek SW, Kim SH et | Cancer Gene Ther | 2026 | 0 |
| Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730] | Zhang Y, Jiang H, Zhang F, Liao J | Neural regeneration research | 2026 | 0 |
| The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859] | Qi L, Yi J, Shen Y, Jiang H, Yao X et al | Biochem Pharmacol | 2026 | 0 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency [PMID:41832996] | Zhang HH, Zhang ZL, Xu W | Reproduction | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactyl [PMID:41946672] | Jiang F, Huang H, Dong Z, Zhang L, Zhang | Cell Death Discov | 2026 | 0 |
| Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepati [PMID:41965824] | Zhang T, Hu L, Chen D, Chen Y, Zhou F et | Nat Commun | 2026 | 0 |
| α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317] | Wu C, Jiang J, Qiu H, Xie J, Li S | Fish Shellfish Immunol | 2026 | 0 |