| Gene Symbol | SIRT3 |
| Full Name | Sirtuin 3 |
| Aliases | Page for SIRT3, Page for SIRT3 Protein |
| Chromosome | 11p15.5 |
| Protein Family | Sirtuin family (Class I) |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | SIRT3 is the primary mitochondrial deacetylase, regulating key metabolic enzymes and proteins involved in |
| Mechanism of Action | Enzyme activation — enhancing SIRT3 deacetylase activity restores mitochondrial protein function and reduces oxidative stress |
| Primary Expression | High in brain, heart, liver, kidney; moderate in skeletal muscle |
| Subcellular Localization | Mitochondria matrix |
| Druggability | Medium (0.61) |
| Clinical Stage | Phase II |
| Molecular Weight | ~44 kDa (full-length), ~28 kDa (processed mature form) |
| Amino Acids | 25 aa |
| Pathways | Akt, Angiogenesis, Apoptosis, Autophagy, Mtor |
| UniProt ID | Q9NWU1 |
| NCBI Gene ID | 23410 |
| Ensembl ID | ENSG00000142092 |
| OMIM | 604479 |
| GeneCards | SIRT3 |
| Human Protein Atlas | SIRT3 |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer'S Disease |
| Known Drugs/Compounds | RAPAMYCIN, Aloe-emodin, Honokiol, Nad, Natural Products, Epigallocatechin gallate |
| Interactions | NRF2, GPX4, EGFR, PLIN2, TP53, SREBF1 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | SIRT3-Mediated Mitochondrial Deacetylation Failure Mitochondrial-Nuclear Epigenetic Cross-Talk Restor |
| KG Connections | 1174 knowledge graph edges |
| Databases | GeneCardsHPASTRING |