gene

SLC9A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC9A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

14Outgoing

3Incoming

0Experiments

0Debates

Summary

SLC9A2 encodes NHE2, a sodium-hydrogen exchanger with roles in ion homeostasis, neuronal function, and potential implications for neurodegeneration

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🧬 Gene Info

Gene Symbol	SLC9A2
Full Name	Solute Carrier Family 9 Member 2 (Na+/H+ Exchanger 2)
Chromosome	2q31.1
Function	is a member of the SLC9A family of sodium-hydrogen antiporters, which play critical roles in maintaining intracellular pH (pHi), cell volume, and sodium homeostasis.
Pathways	Tumor Microenvironment
UniProt ID	Q9Y5E8
NCBI Gene ID	6539
Ensembl ID	ENSG00000165650
OMIM	231336
GeneCards	SLC9A2
Human Protein Atlas	SLC9A2
N-terminal extracellular domain	Contains glycosylation sites important for protein trafficking and function
Transmembrane domain	11-12 alpha-helical segments that form the ion conduction pathway
Hippocampus	Particularly CA1 and CA3 regions, with expression in pyramidal neurons
Cerebral cortex	Layer II-V neurons show NHE2 immunoreactivity
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	CANCER, GENES, STAT3
KG Connections	17 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC9A2 — AlphaFold Q9Y5E8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC9A2 — Solute Carrier Family 9 Member 2 (Na+/H+ Exchanger 2)

gene · 1743 words

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Pathway Diagram

graph TD
    SLC9A2["SLC9A2"]
    Colorectal_Cancer{"Colorectal Cancer"}
    SLC9A2 -->|"inhibits"| Colorectal_Cancer
    Cancer{"Cancer"}
    SLC9A2 -->|"inhibits"| Cancer
    Aging{"Aging"}
    SLC9A2 -->|"inhibits"| Aging
    Tumor{"Tumor"}
    SLC9A2 -->|"inhibits"| Tumor
    CANCER["CANCER"]
    SLC9A2 -->|"inhibits"| CANCER
    GENES["GENES"]
    SLC9A2 -->|"inhibits"| GENES
    VEGFA["VEGFA"]
    SLC9A2 -->|"implicated_in"| VEGFA
    Immunotherapy(["Immunotherapy"])
    SLC9A2 -->|"inhibits"| Immunotherapy
    Epithelial_Mesenchymal_Transition(["Epithelial-Mesenchymal Transition"])
    SLC9A2 -->|"inhibits"| Epithelial_Mesenchymal_Transition
    Invasion(["Invasion"])
    SLC9A2 -->|"implicated_in"| Invasion
    Tumor_Microenvironment(["Tumor Microenvironment"])
    SLC9A2 -->|"activates"| Tumor_Microenvironment
    Immune_Response(["Immune Response"])
    SLC9A2 -->|"therapeutic_target"| Immune_Response
    Metastasis(["Metastasis"])
    SLC9A2 -->|"inhibits"| Metastasis
    Angiogenesis(["Angiogenesis"])
    SLC9A2 -->|"inhibits"| Angiogenesis
    STAT3["STAT3"]
    STAT3 -->|"inhibits"| SLC9A2

Outgoing (14)

Target	Relation	Type	Str
Tumor	inhibits	disease	0.65
Colorectal Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Epithelial-Mesenchymal Transition	inhibits	pathway	0.60
Invasion	implicated_in	pathway	0.60
Tumor Microenvironment	activates	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Metastasis	inhibits	pathway	0.60
VEGFA	implicated_in	gene	0.60
Angiogenesis	inhibits	pathway	0.60
CANCER	inhibits	gene	0.60
GENES	inhibits	gene	0.60
Immunotherapy	inhibits	pathway	0.60

Incoming (3)

Source	Relation	Type	Str
genes-slc9a2	documents	wiki	1.00
genes-slc9a2	describes	wiki	0.90
STAT3	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC9A2 in their description or question text

No additional research found