Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SMAD SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| NEURONS | regulates | cell_type | 0.65 |
| SENESCENCE | regulates | phenotype | 0.65 |
| NEUROGENESIS | treats | phenotype | 0.65 |
| MTOR | associated_with | gene | 0.50 |
| PI3K | associated_with | gene | 0.50 |
| AKT | associated_with | gene | 0.50 |
| FIBROBLASTS | associated_with | cell_type | 0.50 |
| PDGF | associated_with | gene | 0.50 |
| APOE | associated_with | gene | 0.45 |
| SMAD3 | associated_with | gene | 0.45 |
| SMAD2 | associated_with | gene | 0.45 |
| SMAD4 | associated_with | gene | 0.45 |
| GFAP | associated_with | gene | 0.45 |
| NEURONS | associated_with | cell_type | 0.45 |
| NEURON | associated_with | cell_type | 0.45 |
| SENESCENCE | associated_with | phenotype | 0.45 |
| NEUROGENESIS | associated_with | phenotype | 0.45 |
| ALZHEIMER | associated_with | disease | 0.45 |
| ROS | associated_with | phenotype | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ROS | activates | phenotype | 0.65 |
| SMAD3 | converts | gene | 0.60 |
| GLIAL FIBRILLARY ACIDIC PROTEIN | associated_with | biomarker | 0.45 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||