SMAD4

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMAD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SMAD4 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, expressed in. Associated with Als, Alzheimer, Cancer. Connected to 102 entities in the SciDEX knowledge graph.

View on Wiki →

graph TD
    SMAD4["<b>SMAD4</b>"]
    mitophagy(["mitophagy"])
    SMAD4 -->|"regulates"| mitophagy
    Als{"Als"}
    SMAD4 -->|"activates"| Als
    Cancer{"Cancer"}
    SMAD4 -->|"activates"| Cancer
    Tumor{"Tumor"}
    SMAD4 -->|"expressed in"| Tumor
    Ms{"Ms"}
    SMAD4 -->|"activates"| Ms
    SMAD4 -->|"activates"| Tumor
    SMAD4 -->|"expressed in"| Ms
    SMAD2["SMAD2"]
    SMAD4 -->|"regulates"| SMAD2
    LC3["LC3"]
    SMAD4 -->|"activates"| LC3
    Mitophagy(["Mitophagy"])
    SMAD4 -->|"activates"| Mitophagy
    AUTOPHAGY["AUTOPHAGY"]
    SMAD4 -->|"activates"| AUTOPHAGY
    APOPTOSIS["APOPTOSIS"]
    SMAD4 -->|"activates"| APOPTOSIS
    BMPR1A["BMPR1A"]
    BMPR1A -->|"associated with"| SMAD4
    BNIP3["BNIP3"]
    BNIP3 -->|"activates"| SMAD4
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"activates"| SMAD4
    GENES["GENES"]
    GENES -->|"activates"| SMAD4
    TGFB1["TGFB1"]
    TGFB1 -->|"activates"| SMAD4
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"activates"| SMAD4
    SMAD3["SMAD3"]
    SMAD3 -->|"regulates"| SMAD4
    BNIP3L["BNIP3L"]
    BNIP3L -->|"activates"| SMAD4
    TP53["TP53"]
    TP53 -->|"activates"| SMAD4
    MYC["MYC"]
    MYC -->|"activates"| SMAD4
    P62["P62"]
    P62 -->|"activates"| SMAD4
    CANCER["CANCER"]
    CANCER -->|"activates"| SMAD4
    style SMAD4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0