concept

FIBROBLASTS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FIBROBLASTS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

375Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	FIBROBLASTS
Summary	Page for Dura Mater Fibroblasts
Related Diseases	FIBROSIS, CANCER, CHOLESTEROL, ALS, TUMOR GROWTH
Related Pathways	AMPK PATHWAY

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FIBROBLASTS["FIBROBLASTS"]
    FIBROBLASTS -->|"activates"| FIBROSIS["FIBROSIS"]
    FIBROBLASTS -->|"activates"| STEM_CELLS["STEM CELLS"]
    FIBROBLASTS -->|"activates"| IPSC["IPSC"]
    FIBROBLASTS -->|"involved_in"| Wound_Healing["Wound Healing"]
    FIBROBLASTS -->|"contributes to"| Scar_Deposition["Scar Deposition"]
    FIBROBLASTS -->|"expressed in"| miR_3960["miR-3960"]
    FIBROBLASTS -->|"product_of"| Exosomes["Exosomes"]
    FIBROBLASTS -->|"activates"| NEURON["NEURON"]
    CANCER["CANCER"] -->|"interacts"| FIBROBLASTS
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| FIBROBLASTS
    Adaptive_Immune_Cells["Adaptive Immune Cells"] -->|"modulates"| FIBROBLASTS
    SOD1["SOD1"] -->|"regulates"| FIBROBLASTS
    SMC["SMC"] -->|"activates"| FIBROBLASTS
    BDNF["BDNF"] -->|"activates"| FIBROBLASTS

Outgoing (135)

Target	Relation	Type	Str
FIBROSIS	activates	disease	0.95
STEM CELLS	activates	cell_type	0.95
IPSC	activates	cell_type	0.95
NEURON	activates	cell_type	0.80
MACROPHAGES	interacts_with	cell_type	0.65
INFLAMMATION	regulates	process	0.65
CHOLESTEROL	interacts_with	phenotype	0.65
AMPK PATHWAY	regulates	pathway	0.65
TUMOR CELLS	interacts_with	cell_type	0.65
ALS	produces	disease	0.65
TUMOR GROWTH	exacerbates	phenotype	0.65
NICOTINAMIDE	produces	drug	0.65
NEURAL STEM CELLS	activates	cell_type	0.65
PI3K/AKT/MTOR	inhibits	pathway	0.65
STING	causes	gene	0.65
CELL SURVIVAL	regulates	phenotype	0.65
IMMUNE RESPONSE	activates	phenotype	0.65
MITOPHAGY	treats	phenotype	0.60
LEUKEMIA_CELLS	activates	cell_type	0.56
GEMCITABINE	implicated_in	drug	0.55
MACROPHAGES	activates	cell_type	0.50
MOTOR NEURONS	activates	cell_type	0.50
PERICYTES	interacts_with	cell_type	0.50
T CELLS	interacts_with	cell_type	0.50
SENESCENCE	regulates	process	0.50
ROS	regulates	protein	0.50
NEURON	interacts_with	cell_type	0.50
FIBROSIS	regulates	disease	0.50
PULMONARY FIBROSIS	activates	disease	0.50
MTOR	activates	gene	0.50
PI3K	activates	gene	0.50
PARKINSON'S DISEASE	activates	disease	0.50
B CELLS	associated_with	concept	0.50
CELL MIGRATION	activates	concept	0.50
B CELLS	activates	concept	0.50
RESVERATROL	associated_with	concept	0.50
EXTRACELLULAR MATRIX	interacts_with	concept	0.50
CHRONIC INFLAMMATION	interacts_with	concept	0.50
CENTRAL NERVOUS SYSTEM	expressed_in	concept	0.50
NEUTROPHILS	associated_with	concept	0.50
LITHIUM	associated_with	drug	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
RAPAMYCIN	associated_with	drug	0.50
METFORMIN	associated_with	drug	0.45
MELATONIN	associated_with	drug	0.45
CISPLATIN	associated_with	drug	0.45
SPINAL CORD	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
NICOTINAMIDE	associated_with	drug	0.45
GEMCITABINE	associated_with	drug	0.45

Incoming (240)

Source	Relation	Type	Str
CANCER	interacts_with	disease	0.95
AUTOPHAGY	activates	process	0.95
AUTOPHAGY	regulates	process	0.80
CANCER	activates	disease	0.80
METFORMIN	treats	drug	0.65
SNAP25	inhibits	gene	0.65
C9orf72	causes	gene	0.65
ASTROCYTES	produces	cell_type	0.65
NEURONS	produces	cell_type	0.65
C9orf72	transports	gene	0.65
ULK1	phosphorylates	gene	0.65
ULK1	causes	gene	0.65
AUTOPHAGOSOMES	activates	organelle	0.65
AUTOPHAGOSOMES	regulates	organelle	0.65
MYC	activates	gene	0.65
PDGF	activates	gene	0.65
CANCER	causes	disease	0.65
SMC	activates	cell_type	0.64
TH	synergizes_with	gene	0.60
TAU	expressed_in	protein	0.55
AUTOPHAGOSOMES	expressed_in	organelle	0.55
BDNF	activates	gene	0.50
ENDOTHELIAL CELLS	interacts_with	cell_type	0.50
B CELLS	interacts_with	cell_type	0.50
AMPK	activates	gene	0.50
AGING	regulates	process	0.50
ASTROCYTES	regulates	cell_type	0.50
CANCER	regulates	disease	0.50
AKT	activates	gene	0.50
AUTOPHAGY	inhibits	process	0.50
AUTOPHAGY	interacts_with	process	0.50
ALS	associated_with	disease	0.50
MAP6	regulates	gene	0.50
MICROTUBULES	regulates	concept	0.50
DAG1	activates	gene	0.50
IGF1R	activates	gene	0.50
DYSTROGLYCAN	activates	protein	0.50
FIBROSIS	activates	disease	0.50
BCL-2	activates	protein	0.50
HSPG2	activates	concept	0.50
INSULIN	activates	concept	0.50
SPP1	activates	gene	0.50
MACROPHAGES	activates	concept	0.50
PIEZO1	expressed_in	gene	0.50
TRPV4	expressed_in	gene	0.50
CACNA1C	expressed_in	gene	0.50
MACROPHAGES	expressed_in	concept	0.50
MONOCYTES	expressed_in	concept	0.50
APOE3	activates	protein	0.50
APOE4	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FIBROBLASTS

Understanding Entity Pages

Wiki Pages (21)

Dura Mater Fibroblasts

calcium-dysregulation-comparison

nct07165106

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Growth Factor Therapies

Mitochondrial Dysfunction in Parkinson's Disease

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

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VEGF/Angiogenesis Pathway in Neurodegeneration

nlrc5-protein

Mitochondrial Dysfunction in Neurodegeneration

Niemann-Pick Disease Type C (NPC)

Copper Dyshomeostasis in Neurodegeneration

Neuronal Ceroid Lipofuscinosis (NCL)

metal-ion-synuclein-mitochondria-axis-parkinsons

KARS1

Growth Factor Therapeutics: Investment Landscape Analysis

Non-Homologous End Joining in Neurodegeneration

Neuroinflammation-Mitochondria Crosstalk Pathway