protein

SOD1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOD1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Mutations in SOD1 were the first genetic causes identified for amyotrophic lateral sclerosis (ALS), accounting for approximately 12-20% of familial ALS cases and 1-2% of sporadic ALS cases[@gurney1994].

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🔬 Protein Info

Gene Symbol	SOD1PROTEIN
Protein Family	SOD family (Cu/Zn superoxide dismutase)
Function	is a copper-zinc superoxide dismutase encoded by the SOD1 gene that catalyzes the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen[@valentine2020].
Subcellular Localization	to both the cytoplasm and mitochondria[@deng1993]
UniProt ID	P00441
GeneCards	SOD1PROTEIN
Human Protein Atlas	SOD1PROTEIN
Superoxide scavenging	Catalyzes dismutation of O₂⁻ to H₂O₂
Metal homeostasis	Requires copper and zinc for activity
Enzyme coordination	Part of antioxidant network with catalase and glutathione peroxidase
Redox signaling	Modulates cellular redox state[@deng1993]
Cytoplasm	Primary location, ~70% of total cellular SOD1
Mitochondria	Imported through TOM/TIM complexes
Nucleus	Contributes to nuclear redox homeostasis
Extracellular	Minor fraction, may have signaling functions[@borchelt1994]
Associated Diseases	AD, Aging, Als, Alzheimer
Known Drugs/Compounds	Amyloid-Beta Oligomers, antisense oligonucleotides, Antisense Oligonucleotides, ARIMOCLOMOL, CISPLATIN, curcumin
Interactions	ACTB, ACTG1, AD, AGING, AKT, AKT1
KG Connections	2194 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SOD1PROTEIN — AlphaFold P00441 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SOD1 (Cu/Zn Superoxide Dismutase)

protein · 1413 words

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Pathway Diagram

graph TD
    SOD1PROTEIN["SOD1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    SOD1PROTEIN -->|"implicated_in"| neurodegeneration
    style SOD1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SOD1PROTEIN in their description or question text

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