protein

SOD1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOD1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

Summary

Mutations in SOD1 were the first genetic causes identified for amyotrophic lateral sclerosis (ALS), accounting for approximately 12-20% of familial ALS cases and 1-2% of sporadic ALS cases[@gurney1994].

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🔬 Protein Info

Gene Symbol	SOD1PROTEIN
Protein Family	SOD family (Cu/Zn superoxide dismutase)
Function	is a copper-zinc superoxide dismutase encoded by the SOD1 gene that catalyzes the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen[@valentine2020].
Subcellular Localization	to both the cytoplasm and mitochondria[@deng1993]
UniProt ID	P00441
GeneCards	SOD1PROTEIN
Human Protein Atlas	SOD1PROTEIN
Gene	SOD1
PDB	1SPD, 1HL5
Mol. Weight	15.5 kDa (homodimer)
Associated Diseases	AD, ALS, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, ARM, Aging
Known Drugs/Compounds	TOFERSEN, RAPAMYCIN, Lactiplantibacillus plantarum FRT4, Antisense Oligonucleotides, Tofersen, curcumin
Interactions	CALCINEURIN, ATG12, ATG10, GAIN, TNF, PLEKHG5
KG Connections	2095 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SOD1PROTEIN — AlphaFold P00441 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SOD1 (Cu/Zn Superoxide Dismutase)

protein · 1413 words

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Pathway Diagram

graph TD
    SOD1PROTEIN["SOD1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    SOD1PROTEIN -->|"implicated_in"| neurodegeneration
    style SOD1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found