protein 1,413 words KG: SOD1PROTEIN 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

SOD1 (Cu/Zn Superoxide Dismutase)

🔬 Protein Info
Gene SymbolSOD1PROTEIN
Protein FamilySOD family (Cu/Zn superoxide dismutase)
Functionis a copper-zinc superoxide dismutase encoded by the SOD1 gene that catalyzes the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen[@valentine2020].
Subcellular Localizationto both the cytoplasm and mitochondria[@deng1993]
UniProt IDP00441
GeneCardsSOD1PROTEIN
Human Protein AtlasSOD1PROTEIN
GeneSOD1
PDB1SPD, 1HL5
Mol. Weight15.5 kDa (homodimer)
Associated DiseasesAD, ALS, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, ARM, Aging
Known Drugs/CompoundsTOFERSEN, RAPAMYCIN, Lactiplantibacillus plantarum FRT4, Antisense Oligonucleotides, Tofersen, Amyloid-Beta Oligomers
InteractionsCALCINEURIN, ATG12, ATG10, GAIN, TNF, PLEKHG5
KG Connections2095 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (15)

Multiplexed Base Editing for Simultaneous Neuroprotective Ge
Score: 0.53
Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50

Related Analyses (8)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (17)

s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in