| Gene Symbol | SOD1PROTEIN |
| Protein Family | SOD family (Cu/Zn superoxide dismutase) |
| Function | is a copper-zinc superoxide dismutase encoded by the SOD1 gene that catalyzes the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen[@valentine2020]. |
| Subcellular Localization | to both the cytoplasm and mitochondria[@deng1993] |
| UniProt ID | P00441 |
| GeneCards | SOD1PROTEIN |
| Human Protein Atlas | SOD1PROTEIN |
| Superoxide scavenging | Catalyzes dismutation of O₂⁻ to H₂O₂ |
| Metal homeostasis | Requires copper and zinc for activity |
| Enzyme coordination | Part of antioxidant network with catalase and glutathione peroxidase |
| Redox signaling | Modulates cellular redox state[@deng1993] |
| Cytoplasm | Primary location, ~70% of total cellular SOD1 |
| Mitochondria | Imported through TOM/TIM complexes |
| Nucleus | Contributes to nuclear redox homeostasis |
| Extracellular | Minor fraction, may have signaling functions[@borchelt1994] |
| Associated Diseases | AD, Aging, Als, Alzheimer |
| Known Drugs/Compounds | Amyloid-Beta Oligomers, antisense oligonucleotides, Antisense Oligonucleotides, ARIMOCLOMOL, CISPLATIN, curcumin |
| Interactions | ACTB, ACTG1, AD, AGING, AKT, AKT1 |
| KG Connections | 2194 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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