gene

STEAP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STEAP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

6Outgoing

6Incoming

0Experiments

0Debates

Summary

steap3

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🧬 Gene Info

Gene Symbol	STEAP3
Chromosome	12.
Protein Type	Gene
Function	STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3) encodes a metalloreductase that facilitates iron and copper uptake into cells.
Subcellular Localization	endosomal and plasma membranes, where it reduces extracellular and intracellular ferric iron to ferrous iron. This reduc
Pathways	Autophagy, Mapk
GeneCards	STEAP3
Human Protein Atlas	STEAP3
DMT1 (SLC11A2)	Iron transporter dependent on STEAP3-mediated reduction
Ferroportin (SLC40A1)	Iron exporter working
Associated Diseases	neurodegeneration
Interactions	AND, AUTOPHAGY, INFLAMMATION, JAK, MAPK, RAB7A
KG Connections	12 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

steap3

gene · 657 words

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Pathway Diagram

graph TD
    STEAP3["STEAP3"]
    Ms{"Ms"}
    STEAP3 -->|"activates"| Ms
    Inflammation{"Inflammation"}
    STEAP3 -->|"activates"| Inflammation
    INFLAMMATION["INFLAMMATION"]
    STEAP3 -->|"activates"| INFLAMMATION
    AUTOPHAGY["AUTOPHAGY"]
    STEAP3 -->|"inhibits"| AUTOPHAGY
    Autophagy(["Autophagy"])
    STEAP3 -->|"inhibits"| Autophagy
    Mapk(["Mapk"])
    STEAP3 -->|"activates"| Mapk
    neurodegeneration["neurodegeneration"]
    STEAP3 -->|"implicated in"| neurodegeneration
    RAB7A["RAB7A"]
    RAB7A -->|"activates"| STEAP3
    JAK["JAK"]
    JAK -->|"activates"| STEAP3
    style STEAP3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
INFLAMMATION	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
Autophagy	inhibits	pathway	0.60
Mapk	activates	pathway	0.60

Incoming (6)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	0.60
MAPK	activates	gene	0.60
GENES	associated_with	gene	0.60
AND	activates	gene	0.60
RAB7A	activates	gene	0.60
JAK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STEAP3 in their description or question text

No additional research found