Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STEAP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | STEAP3 |
| Chromosome | 12. |
| Protein Type | Gene |
| Function | STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3) encodes a metalloreductase that facilitates iron and copper uptake into cells. |
| Subcellular Localization | endosomal and plasma membranes, where it reduces extracellular and intracellular ferric iron to ferrous iron. This reduc |
| Pathways | Autophagy, Mapk |
| GeneCards | STEAP3 |
| Human Protein Atlas | STEAP3 |
| DMT1 (SLC11A2) | Iron transporter dependent on STEAP3-mediated reduction |
| Ferroportin (SLC40A1) | Iron exporter working |
| Associated Diseases | neurodegeneration |
| Interactions | INFLAMMATION, AUTOPHAGY, RAB7A, JAK, AND, MAPK |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
STEAP3["<b>STEAP3</b>"]
Ms{"Ms"}
STEAP3 -->|"activates"| Ms
Inflammation{"Inflammation"}
STEAP3 -->|"activates"| Inflammation
INFLAMMATION["INFLAMMATION"]
STEAP3 -->|"activates"| INFLAMMATION
AUTOPHAGY["AUTOPHAGY"]
STEAP3 -->|"inhibits"| AUTOPHAGY
Autophagy(["Autophagy"])
STEAP3 -->|"inhibits"| Autophagy
Mapk(["Mapk"])
STEAP3 -->|"activates"| Mapk
neurodegeneration["neurodegeneration"]
STEAP3 -->|"implicated in"| neurodegeneration
RAB7A["RAB7A"]
RAB7A -->|"activates"| STEAP3
JAK["JAK"]
JAK -->|"activates"| STEAP3
style STEAP3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| INFLAMMATION | activates | gene | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| Mapk | activates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||