gene

TNFAIP6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFAIP6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

11Outgoing

5Incoming

Summary

TNFAIP6 is a gene implicated in neurodegeneration research. Key relationships include: activates, biomarker for, implicated in. Associated with Als, Diabetes, Ischemia. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TNFAIP6
Full Name	TNF Alpha Induced Protein 6 (TSG-6)
Chromosome	2p23.3
Function	is a secreted glycoprotein that plays crucial roles in cell adhesion, inflammatory responses, and extracellular matrix organization [1].
Primary Expression	a variety of tissues and cell types, with particularly high expression in inflamed tissues, activated leukocytes, and stromal cells [3]
Molecular Weight	35 kDa
Amino Acids	354 aa
Exons	7
Pathways	NF-κB
UniProt ID	[P20742](https://www.uniprot.org/uniprot/P20742)
Ensembl ID	ENSG00000123607
OMIM	191163
GeneCards	TNFAIP6
Human Protein Atlas	TNFAIP6
NF-κB binding sites	Mediate TNF-α induced expression
Associated Diseases	neurodegeneration
Interactions	CHI3L1, MMP1, HIF1A, MMP3, ASTROCYTES
KG Connections	16 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TNFAIP6["<b>TNFAIP6</b>"]
    Diabetes{"Diabetes"}
    TNFAIP6 -->|"activates"| Diabetes
    Als{"Als"}
    TNFAIP6 -->|"activates"| Als
    Ischemia{"Ischemia"}
    TNFAIP6 -->|"activates"| Ischemia
    Ms{"Ms"}
    TNFAIP6 -->|"biomarker for"| Ms
    Tumor{"Tumor"}
    TNFAIP6 -->|"activates"| Tumor
    CHI3L1["CHI3L1"]
    TNFAIP6 -->|"activates"| CHI3L1
    HSP70["HSP70"]
    TNFAIP6 -->|"biomarker for"| HSP70
    APOPTOSIS["APOPTOSIS"]
    TNFAIP6 -->|"biomarker for"| APOPTOSIS
    Apoptosis(["Apoptosis"])
    TNFAIP6 -->|"biomarker for"| Apoptosis
    Nf__b(["Nf-Kappab"])
    TNFAIP6 -->|"biomarker for"| Nf__b
    Blood_Brain_Barrier(["Blood-Brain Barrier"])
    TNFAIP6 -->|"biomarker for"| Blood_Brain_Barrier
    neurodegeneration["neurodegeneration"]
    TNFAIP6 -->|"implicated in"| neurodegeneration
    MMP1["MMP1"]
    MMP1 -->|"activates"| TNFAIP6
    HIF1A["HIF1A"]
    HIF1A -->|"activates"| TNFAIP6
    MMP3["MMP3"]
    MMP3 -->|"activates"| TNFAIP6
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| TNFAIP6
    NF__B["NF-KappaB"]
    NF__B -->|"biomarker for"| TNFAIP6
    style TNFAIP6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
Diabetes	activates	disease	0.65
Als	activates	disease	0.65
Ischemia	activates	disease	0.65
Ms	biomarker_for	disease	0.65
Tumor	activates	disease	0.65
CHI3L1	activates	gene	0.60
HSP70	biomarker_for	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
Apoptosis	biomarker_for	pathway	0.60
Nf-Κb	biomarker_for	pathway	0.60
Blood-Brain Barrier	biomarker_for	pathway	0.60

Incoming (5)

Source	Relation	Type	Str
MMP1	activates	gene	0.60
HIF1A	activates	gene	0.60
MMP3	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
NF-ΚB	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found