gene

MMP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MMP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

139Connections
0Hypotheses
0Analyses
50Outgoing
49Incoming

Summary

MMP3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, Als, Arthritis. Connected to 80 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolMMP3
Chromosome11q22.3.
FunctionMMP3 encodes matrix metalloproteinase 3 (MMP-3), also known as stromelysin-1, a member of the zinc-dependent metalloproteinase family.
PathwaysFerroptosis, Synaptic Plasticity, Long-Term Potentiation, Oxidative Stress, Apoptosis
Ensembl IDENSG00000149968
GeneCardsMMP3
Human Protein AtlasMMP3
Associated DiseasesAtherosclerosis, Inflammation, Stroke
Known Drugs/Compoundsicariin
InteractionsGPX4, SOX9, SLC7A11, MMP1, FER, TNFAIP6
KG Connections139 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

MMP3 Gene

gene · 582 words

amyloid-beta-metalloproteinases

mechanism · 4656 words

cGAS-STING Signaling in Parkinson's Disease

mechanism · 3408 words

Astrocyte Senescence Pathway in Neurodegeneration

mechanism · 2947 words

Cellular Senescence Hypothesis in Parkinson's Disease

hypothesis · 2663 words

TNFAIP6 — TNF Alpha Induced Protein 6 (TSG-6)

gene · 1900 words

Pathway Diagram

flowchart TD
    MMP3["MMP3"] -->|"activates"| Als["Als"]
    MMP3["MMP3"] -.->|"inhibits"| Ms["Ms"]
    MMP3["MMP3"] -.->|"inhibits"| Depression["Depression"]
    MMP3["MMP3"] -->|"therapeutic target"| Stroke["Stroke"]
    MMP3["MMP3"] -->|"therapeutic target"| Ischemia["Ischemia"]
    MMP3["MMP3"] -->|"therapeutic target"| Ms["Ms"]
    MMP3["MMP3"] -.->|"inhibits"| Als["Als"]
    MMP3["MMP3"] -.->|"inhibits"| Arthritis["Arthritis"]
    MMP3["MMP3"] -->|"expressed in"| Ms["Ms"]
    MMP3["MMP3"] -->|"expressed in"| Cancer["Cancer"]
    MMP3["MMP3"] -->|"activates"| Diabetes["Diabetes"]
    MMP3["MMP3"] -->|"expressed in"| Neuroinflammation["Neuroinflammation"]
    style MMP3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Depression fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ischemia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Arthritis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (90)

TargetRelationTypeStr
APOEassociated_withgene0.70
GENESassociated_withgene0.70
Arthritisinhibitsdisease0.65
Alsactivatesdisease0.65
Msinhibitsdisease0.65

Incoming (49)

SourceRelationTypeStr
KDM6Ainhibitsgene0.70
MMP9inhibitsgene0.60
SSTinhibitsgene0.60
GPX4activatesgene0.60
SLC7A11activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found