Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRIM11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TRIM11 (Tripartite Motif Containing 11) — brain-expressed E3 ubiquitin ligase regulating protein quality control, amyloid clearance, and neuronal survival in Alzheimer's disease and prion disease
| Gene Symbol | TRIM11 |
| Full Name | TRIM11 |
| Aliases | Tripartite Motif Containing 11 |
| Chromosome | 1q42.13 |
| Protein Type | Gene |
| Function | encodes a protein of approximately 462 amino acids with a molecular weight of approximately 52 kDa. |
| Primary Expression | the brain, with high expression in the cerebral cortex, hippocampus, [cerebellum](/brain-region |
| Molecular Weight | 52 kDa |
| Amino Acids | 462 aa |
| Pathways | Proteasomal Degradation |
| NCBI Gene ID | Search NCBI |
| GeneCards | TRIM11 |
| Human Protein Atlas | TRIM11 |
| Associated Diseases | Inflammation, Neuroinflammation, Neuron Viability, Tau Solubility |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
TRIM11["<b>TRIM11</b>"]
Tau_Aggregation["Tau Aggregation"]
TRIM11 -.->|"inhibits"| Tau_Aggregation
Alzheimer_s_Disease{"Alzheimer's Disease"}
TRIM11 -.->|"downregulates"| Alzheimer_s_Disease
TAU(["TAU"])
TRIM11 -->|"degrades"| TAU
Tauopathies{"Tauopathies"}
TRIM11 -->|"protects_against"| Tauopathies
Proteasomal_Degradation["Proteasomal Degradation"]
TRIM11 -->|"involved_in"| Proteasomal_Degradation
Tau_Solubility["Tau Solubility"]
TRIM11 -->|"associated_with"| Tau_Solubility
NEUROINFLAMMATION["NEUROINFLAMMATION"]
NEUROINFLAMMATION -->|"treats"| TRIM11
style TRIM11 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | downregulates | disease | 0.95 |
| Tau Aggregation | inhibits | process | 0.95 |
| TAU | degrades | protein | 0.90 |
| Proteasomal Degradation | involved_in | process | 0.90 |
| Tau Solubility | associated_with | phenotype | 0.90 |
| Tauopathies | protects_against | disease | 0.90 |
| Tau Fibrils | associated_with | process | 0.85 |
| Tau Misfolding | inhibits | process | 0.85 |
| Neuron Viability | associated_with | phenotype | 0.85 |
| Neuroinflammation | modulates | process | 0.85 |
| Cognitive Impairment | modulates | phenotype | 0.85 |
| Alzheimer | regulates | disease | 0.65 |
| Neuroinflammation | associated_with | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| TAU | regulates | gene | 0.60 |
| neuroinflammation | interacts_with | disease | 0.60 |
| AND | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| NEUROINFLAMMATION | associated_with | gene | 0.60 |
| Actin | regulates | protein | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| ALZHEIMER | regulates | gene | 0.50 |
| Alzheimer'S Disease | regulates | disease | 0.50 |
| disease | regulates | disease | 0.50 |
| ALZHEIMER'S | regulates | concept | 0.50 |
| NEURONS | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TAU | activates | entity | 0.60 |
| NEUROINFLAMMATION | treats | entity | 0.60 |
| TAU | regulates | gene | 0.60 |
| NEUROINFLAMMATION | associated_with | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| Neuroinflammation | inhibits | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||