Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRPC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TRPC1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Hypertension. Connected to 11 entities in the SciDEX knowledge graph.
| Gene Symbol | TRPC1 |
| Full Name | Transient Receptor Potential Cation Channel Subfamily C Member 1 |
| Chromosome | 3q23 |
| Protein Type | Channel |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Ubiquitous - Brain, Heart, Skeletal muscle, Endothelium |
| Molecular Weight | 90 kDa |
| Amino Acids | 793 aa |
| Exons | 13 |
| UniProt ID | P48995 |
| NCBI Gene ID | 7220 |
| Ensembl ID | ENSG00000113615 |
| OMIM | 602409 |
| GeneCards | TRPC1 |
| Human Protein Atlas | TRPC1 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Stroke |
| Interactions | TRPV4, FSP1, PIEZO1, KCNK2, Rb, GENES |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TRPC1["<b>TRPC1</b>"]
Hypertension{"Hypertension"}
TRPC1 -->|"activates"| Hypertension
TRPC1 -->|"regulates"| Hypertension
TRPV4["TRPV4"]
TRPC1 -->|"activates"| TRPV4
FSP1["FSP1"]
TRPC1 -->|"activates"| FSP1
GENES["GENES"]
TRPC1 -->|"activates"| GENES
PIEZO1["PIEZO1"]
TRPC1 -->|"activates"| PIEZO1
KCNK2["KCNK2"]
TRPC1 -->|"activates"| KCNK2
AND["AND"]
TRPC1 -->|"activates"| AND
neurodegeneration["neurodegeneration"]
TRPC1 -->|"implicated in"| neurodegeneration
PIEZO1 -->|"activates"| TRPC1
KCNK2 -->|"activates"| TRPC1
FSP1 -->|"activates"| TRPC1
style TRPC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Hypertension | activates | disease | 0.65 |
| Hypertension | regulates | disease | 0.65 |
| TRPV4 | activates | gene | 0.60 |
| FSP1 | activates | gene | 0.60 |
| PIEZO1 | activates | gene | 0.60 |
| KCNK2 | activates | gene | 0.60 |
| TRPV4 | inhibits | entity | 0.60 |
| Rb | activates | protein | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| GENES | activates | gene | 0.60 |
| TREK-1 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| PIEZO | activates | gene | 0.60 |
| Fus | activates | protein | 0.60 |
| TRPV4 | co_discussed | gene | 0.50 |
| WAS | co_discussed | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PIEZO1 | activates | gene | 0.60 |
| KCNK2 | activates | gene | 0.60 |
| FSP1 | activates | gene | 0.60 |
| FSP1 | inhibits | entity | 0.60 |
| KCNK2 | inhibits | entity | 0.60 |
| PIEZO1 | inhibits | entity | 0.60 |
| TRPV4 | activates | gene | 0.60 |
| APOE4 | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| TREK-1 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| PIEZO | activates | gene | 0.60 |
| FOXO | activates | gene | 0.60 |
| FSP1 | co_discussed | gene | 0.50 |
| KCNK2 | expressed_in | gene | 0.50 |
| PIEZO1 | co_discussed | gene | 0.50 |
| GENES | co_discussed | gene | 0.50 |
| TREK-1 | co_discussed | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||