concept

TRPML2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPML2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

21Outgoing

9Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	TRPML2
Key Genes/Proteins	TRPML1, GENES, AUTOPHAGY, JUN, AND, MCOLN1
Related Diseases	Neurodegeneration, ALS, Als
Related Pathways	Autophagy, Calcium Signaling

Wiki Pages (1)

Knowledge base pages for this entity

Lysosomal Calcium Dysregulation in Neurodegeneration

mechanism · 2791 words

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Pathway Diagram

graph TD
    TRPML2["TRPML2"]
    TRPML2 -->|"co_expressed_with"| TRPML1["TRPML1"]
    TRPML2 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    TRPML2 -->|"expressed in"| ALS["ALS"]
    TRPML2 -->|"expressed in"| Als["Als"]
    TRPML2 -->|"expressed in"| GENES["GENES"]
    TRPML2 -->|"expressed in"| AUTOPHAGY["AUTOPHAGY"]
    TRPML2 -->|"regulates"| JUN["JUN"]
    TRPML2 -->|"expressed in"| AND["AND"]
    MCOLN1["MCOLN1"] -->|"regulates"| TRPML2
    LYSOSOME["LYSOSOME"] -->|"regulates"| TRPML2
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| TRPML2
    TRPML3["TRPML3"] -->|"expressed in"| TRPML2
    TRPML1 -->|"expressed in"| TRPML2
    AUTOPHAGY -->|"expressed in"| TRPML2
    JUN -->|"regulates"| TRPML2

Outgoing (21)

Target	Relation	Type	Str
TRPML1	interacts_with	protein	0.80
TRPML1	co_expressed_with	protein	0.70
Neurodegeneration	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
GENES	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
JUN	regulates	gene	0.60
AND	expressed_in	gene	0.60
Autophagy	expressed_in	pathway	0.60
Calcium Signaling	regulates	pathway	0.60
TRPML1	expressed_in	gene	0.60
MCOLN1	regulates	gene	0.60
TRPML3	expressed_in	gene	0.60
Fibroblast	regulates	cell_type	0.60
Raf	expressed_in	protein	0.60
App	regulates	protein	0.60
TRPML3	translocates_to	gene	0.60
autophagy pathway	participates_in	pathway	0.60
TRPML3	associated_with	gene	0.60
Fibroblast	expressed_in	cell_type	0.55

Incoming (9)

Source	Relation	Type	Str
MCOLN1	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
TRPML3	expressed_in	gene	0.60
TRPML1	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
JUN	regulates	gene	0.60
TRPML1	translocates_to	gene	0.60
TRPML1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found