concept

TRPML3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPML3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

20Outgoing

11Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	TRPML3
Key Genes/Proteins	TRPML1, TRPML2, GENES, AUTOPHAGY, JUN, AND
Related Diseases	Neurodegeneration, ALS, Als
Related Pathways	Autophagy, Calcium Signaling

Wiki Pages (1)

Knowledge base pages for this entity

Lysosomal Calcium Dysregulation in Neurodegeneration

mechanism · 2791 words

→

Pathway Diagram

graph TD
    TRPML3["TRPML3"]
    TRPML3 -->|"co_expressed_with"| TRPML1["TRPML1"]
    TRPML3 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    TRPML3 -->|"expressed in"| ALS["ALS"]
    TRPML3 -->|"expressed in"| Als["Als"]
    TRPML3 -->|"expressed in"| TRPML2["TRPML2"]
    TRPML3 -->|"expressed in"| GENES["GENES"]
    TRPML3 -->|"expressed in"| AUTOPHAGY["AUTOPHAGY"]
    MCOLN1["MCOLN1"] -->|"regulates"| TRPML3
    LYSOSOME["LYSOSOME"] -->|"regulates"| TRPML3
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| TRPML3
    TRPML2 -->|"expressed in"| TRPML3
    TRPML1 -->|"expressed in"| TRPML3
    AUTOPHAGY -->|"expressed in"| TRPML3
    JUN["JUN"] -->|"regulates"| TRPML3

Outgoing (20)

Target	Relation	Type	Str
TRPML1	interacts_with	protein	0.80
TRPML1	co_expressed_with	protein	0.70
Neurodegeneration	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
TRPML1	expressed_in	gene	0.60
TRPML2	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
JUN	regulates	gene	0.60
AND	expressed_in	gene	0.60
Autophagy	expressed_in	pathway	0.60
Calcium Signaling	regulates	pathway	0.60
Fibroblast	regulates	cell_type	0.60
MCOLN1	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
Raf	expressed_in	protein	0.60
App	regulates	protein	0.60
autophagy pathway	participates_in	pathway	0.60
Fibroblast	expressed_in	cell_type	0.55

Incoming (11)

Source	Relation	Type	Str
MCOLN1	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
TRPML2	expressed_in	gene	0.60
TRPML1	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
JUN	regulates	gene	0.60
TRPML1	translocates_to	gene	0.60
TRPML2	translocates_to	gene	0.60
TRPML1	associated_with	gene	0.60
TRPML2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found