Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VAV2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | VAV2 |
| Key Genes/Proteins | RAC1, Vimentin, VIM, VIMENTIN, TNF-Α, TNF |
| Related Diseases | Autoimmune, Inflammation |
| Related Pathways | Autophagy, Apoptosis |
Knowledge base pages for this entity
graph TD
VAV2["VAV2"]
VAV2 -->|"phosphorylates"| RAC1["RAC1"]
VAV2 -->|"expressed in"| Autoimmune["Autoimmune"]
VAV2 -->|"expressed in"| Inflammation["Inflammation"]
VAV2 -->|"inhibits"| VIMENTIN["VIMENTIN"]
VAV2 -->|"expressed in"| TNF__["TNF-Alpha"]
VAV2 -->|"expressed in"| Autophagy["Autophagy"]
VAV2 -->|"expressed in"| Apoptosis["Apoptosis"]
VAV2 -->|"expressed in"| TNF["TNF"]
Vimentin["Vimentin"] -->|"activates"| VAV2
VIM["VIM"] -->|"activates"| VAV2
INFLAMMATION["INFLAMMATION"] -->|"expressed in"| VAV2
TNF -->|"expressed in"| VAV2
APOPTOSIS["APOPTOSIS"] -->|"expressed in"| VAV2
AUTOPHAGY["AUTOPHAGY"] -->|"expressed in"| VAV2
RNA["RNA"] -->|"expressed in"| VAV2
AND["AND"] -->|"activates"| VAV2| Target | Relation | Type | Str |
|---|---|---|---|
| RAC1 | phosphorylates | protein | 0.85 |
| Autoimmune | expressed_in | disease | 0.65 |
| Inflammation | expressed_in | disease | 0.65 |
| VIMENTIN | inhibits | gene | 0.60 |
| TNF-Α | expressed_in | gene | 0.60 |
| Autophagy | expressed_in | pathway | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| TNF | expressed_in | gene | 0.60 |
| INFLAMMATION | expressed_in | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| AND | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||