VIM

Understanding Entity Pages

This page aggregates everything SciDEX knows about VIM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

VIM is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, biomarker for. Associated with ALS, Aging, Als. Connected to 209 entities in the SciDEX knowledge graph.

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flowchart TD
    VIM["VIM<br/>(Vimentin)"]
    
    %% Autophagy pathway
    BECN1["BECN1<br/>(Beclin-1)"]
    MAP1LC3B["MAP1LC3B<br/>(LC3B)"]
    ATG14["ATG14<br/>(Autophagy Protein)"]
    PIK3C3["PIK3C3<br/>(VPS34)"]
    UVRAG["UVRAG<br/>(Autophagy Regulator)"]
    LAMP1["LAMP1<br/>(Lysosomal Protein)"]
    Autophagy["Autophagy<br/>Pathway"]
    
    %% Protein degradation
    UPS["Ubiquitin-Proteasome<br/>System"]
    HDAC6["HDAC6<br/>(Histone Deacetylase)"]
    
    %% Cellular stress
    H2AX["H2AX<br/>(DNA Damage Marker)"]
    MAP3K5["MAP3K5<br/>(ASK1 Kinase)"]
    
    %% Disease outcomes
    Inflammation["Neuroinflammation"]
    Senescence["Cellular<br/>Senescence"]
    ALS["Amyotrophic Lateral<br/>Sclerosis (ALS)"]
    PD["Parkinson's<br/>Disease"]
    MS["Multiple<br/>Sclerosis"]
    
    %% Connections
    VIM --|"regulates"|--> BECN1
    VIM --|"regulates"|--> ATG14
    VIM --|"regulates"|--> Autophagy
    VIM --|"associated with"|--> MAP1LC3B
    VIM --|"associated with"|--> PIK3C3
    VIM --|"associated with"|--> UVRAG
    VIM --|"associated with"|--> LAMP1
    VIM --|"regulates"|--> UPS
    VIM --|"associated with"|--> HDAC6
    VIM --|"regulates"|--> H2AX
    VIM --|"associated with"|--> MAP3K5
    
    BECN1 --|"initiates"|--> Autophagy
    ATG14 --|"promotes"|--> Autophagy
    MAP1LC3B --|"mediates"|--> Autophagy
    PIK3C3 --|"activates"|--> Autophagy
    UVRAG --|"regulates"|--> Autophagy
    LAMP1 --|"completes"|--> Autophagy
    
    VIM --|"biomarker for"|--> Inflammation
    VIM --|"biomarker for"|--> Senescence
    VIM --|"biomarker for"|--> ALS
    VIM --|"therapeutic target"|--> PD
    VIM --|"therapeutic target"|--> MS
    
    H2AX --|"indicates"|--> Senescence
    MAP3K5 --|"promotes"|--> Inflammation
    
    %% Styling
    style VIM fill:#006494
    style Autophagy fill:#1b5e20
    style UPS fill:#1b5e20
    style BECN1 fill:#4a1a6b
    style ATG14 fill:#4a1a6b
    style HDAC6 fill:#4a1a6b
    style Inflammation fill:#ef5350
    style Senescence fill:#ef5350
    style ALS fill:#5d4400
    style PD fill:#5d4400
    style MS fill:#5d4400