protein

VIMENTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VIMENTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

328Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Type III intermediate filament protein expressed in astrocytes, marker of neuroinflammation in neurodegenerative diseases

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🔬 Protein Info

Gene Symbol	VIMENTIN
Chromosome	10p13
Protein Family	Type III intermediate filament protein
Function	is a type III intermediate filament protein encoded by the VIM gene.
Primary Expression	mesenchymal cells, fibroblasts, and astrocytes in the central nervous system
Subcellular Localization	Cytoplasm, intermediate filaments
Molecular Weight	57 kDa
Amino Acids	466 aa
Pathways	Autophagy, NOTCH_SIGNALING, Notch Signal Sending, Notch Signaling, Proteasome
UniProt ID	P08670
GeneCards	VIMENTIN
Human Protein Atlas	VIMENTIN
Central α-helical rod domain	Responsible for dimerization and filament assembly PMID: 2847424
N-terminal head domain	Regulates filament assembly and interaction with signaling molecules PMID: 21855637
C-terminal tail domain	Mediates interactions with other cytoskeletal elements and organelles PMID: 8898344
Associated Diseases	Glioblastoma, Ms, Tumor
Known Drugs/Compounds	columbianadin
Interactions	FNDC5, FGF21, SOX2, GFAP, NOTCH1, DLK2
KG Connections	325 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: VIMENTIN — AlphaFold P08670 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VIMENTIN["VIMENTIN"]
    VIMENTIN -.biomarker for.-> Aging["Aging"]
    VIMENTIN -.biomarker for.-> Inflammation["Inflammation"]
    VIMENTIN -.biomarker for.-> ALS["ALS"]
    VIMENTIN -.biomarker for.-> Senescence["Senescence"]
    VIMENTIN -.biomarker for.-> Fibrosis["Fibrosis"]
    VIMENTIN -->|"regulates"| NOTCH_SIGNALING["NOTCH_SIGNALING"]
    VIMENTIN -->|"regulates"| ATG14["ATG14"]
    VIMENTIN -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
    VIMENTIN -->|"regulates"| Proteasome["Proteasome"]
    LYSOSOME["LYSOSOME"] -->|"regulates"| VIMENTIN
    GJA1["GJA1"] -->|"regulates"| VIMENTIN
    CASP3["CASP3"] -->|"regulates"| VIMENTIN
    GAPDH["GAPDH"] -->|"regulates"| VIMENTIN
    ACTB["ACTB"] -->|"regulates"| VIMENTIN
    CDC42["CDC42"] -->|"regulates"| VIMENTIN
    BECN1["BECN1"] -->|"regulates"| VIMENTIN
    H2AX["H2AX"] -->|"regulates"| VIMENTIN
    GPNMB["GPNMB"] -.biomarker for.-> VIMENTIN
    CX3CL1["CX3CL1"] -->|"activates"| VIMENTIN

Outgoing (198)

Target	Relation	Type	Str
Notch Signaling	regulates	pathway	0.85
Notch Signal Sending	regulates	mechanism	0.85
Notch Signal Sending Competence	modulates	phenotype	0.75
VAV2/Rac-1 signaling pathway	inhibits	pathway	0.70
Aging	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
ALS	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	inhibits	disease	0.65
Glioblastoma	associated_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Autoimmune	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Als	expressed_in	disease	0.65
Fibrosis	activates	disease	0.65
Als	regulates	disease	0.65
Epilepsy	activates	disease	0.65
ALS	transports	disease	0.65
Als	transports	disease	0.65
Diabetes	activates	disease	0.65
NOTCH_SIGNALING	regulates	pathway	0.64
ATG14	regulates	gene	0.60
C1Q	biomarker_for	gene	0.60
FNDC5	activates	gene	0.60
FGF21	activates	gene	0.60
NESTIN	expressed_in	gene	0.60
SOX2	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
NOTCH1	inhibits	gene	0.60
ALDH1L1	expressed_in	gene	0.60
EGF	expressed_in	gene	0.60
DLK2	inhibits	gene	0.60
MAP3K5	associated_with	gene	0.60
TCF4	activates	gene	0.60
FOXP3	activates	gene	0.60
MMP9	activates	gene	0.60
TNF	expressed_in	gene	0.60
VIM	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
GAPDH	regulates	gene	0.60
UVRAG	associated_with	gene	0.60
CASP3	regulates	gene	0.60
BECN1	regulates	gene	0.60

Incoming (130)

Source	Relation	Type	Str
HIF-1Α	upregulates	gene	0.90
columbianadin	targets	compound	0.70
TUBULIN	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP3K5	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
OCLN	associated_with	gene	0.60
GJA1	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
CASP3	regulates	gene	0.60
GAPDH	regulates	gene	0.60
ACTB	regulates	gene	0.60
TUBB3	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
STK11	associated_with	gene	0.60
VIM	associated_with	gene	0.60
CDC42	regulates	gene	0.60
HDAC6	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
BECN1	regulates	gene	0.60
H2AX	regulates	gene	0.60
GPNMB	biomarker_for	gene	0.60
CX3CL1	activates	gene	0.60
PROGRANULIN	activates	gene	0.60
APP	biomarker_for	gene	0.60
CXCL10	activates	gene	0.60
BDNF	activates	gene	0.60
FGF23	activates	gene	0.60
PLAU	activates	gene	0.60
VIM	activates	gene	0.60
S100B	biomarker_for	gene	0.60
HMGB1	biomarker_for	gene	0.60
TGM2	biomarker_for	gene	0.60
ATG14	regulates	gene	0.60
GBM	associated_with	gene	0.60
DRP1	associated_with	gene	0.60
MMP9	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
RAB32	associated_with	gene	0.60
C1Q	biomarker_for	gene	0.60
FNDC5	activates	gene	0.60
FGF21	activates	gene	0.60
ALDH1L1	expressed_in	gene	0.60
GFAP	inhibits	gene	0.60
NESTIN	expressed_in	gene	0.60
EGF	expressed_in	gene	0.60
NOTCH1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VIMENTIN

Understanding Entity Pages

Summary

Wiki Pages (21)

Vimentin - Biomarker

Glia-Neuron Crosstalk in Alzheimer's Disease

Astrocytes

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

Litronesib (LY317615/Enzastaurin)

PRDX2 — Peroxiredoxin 2

Neuronal Migration

Tanycytes: A Novel Tau Clearance Pathway from Brain to Blood

Tanycytes

Zombosomes — Anucleated Cell Couriers in Alpha-Synuclein Propagation

PLIN1 — Perilipin 1

Caspase-3 Protein

alexander-disease

Chondrogenesis (Neural)

CRYAB Gene

Meningeal Fibroblasts

Glial Fibrillary Acidic Protein (GFAP)

PLEC Gene

ARHGAP5 Gene