UVRAG

Understanding Entity Pages

This page aggregates everything SciDEX knows about UVRAG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

UVRAG is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Cancer. Connected to 193 entities in the SciDEX knowledge graph.

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flowchart TD
    UVRAG["UVRAG<br/>UV Radiation Resistance<br/>Associated Gene"]
    
    PIK3C3["PIK3C3<br/>Class III PI3K"]
    ATG14["ATG14<br/>Autophagy Protein"]
    MTOR["MTOR<br/>Mechanistic Target<br/>of Rapamycin"]
    
    Autophagy["Autophagy<br/>Pathway"]
    UPS["Ubiquitin-Proteasome<br/>System"]
    Proteasome["Proteasome<br/>Pathway"]
    
    APP["APP<br/>Amyloid Precursor<br/>Protein"]
    H2AX["H2AX<br/>DNA Damage<br/>Response"]
    RAC1["RAC1<br/>Small GTPase"]
    
    Neurodegeneration["Neurodegeneration<br/>Disease Process"]
    Parkinsons["Parkinson's<br/>Disease"]
    ALS["ALS<br/>Amyotrophic Lateral<br/>Sclerosis"]
    MS["Multiple<br/>Sclerosis"]
    
    Aging["Cellular<br/>Aging"]
    DNADamage["DNA Damage<br/>Accumulation"]
    
    UVRAG --|"forms complex"|--> PIK3C3
    UVRAG --|"regulates"|--> ATG14
    UVRAG --|"regulates"|--> Autophagy
    UVRAG --|"regulates"|--> UPS
    UVRAG --|"regulates"|--> Proteasome
    
    PIK3C3 --|"activates"|--> Autophagy
    ATG14 --|"promotes"|--> Autophagy
    MTOR --|"inhibits"|--> Autophagy
    UVRAG --|"associated with"|--> MTOR
    
    UVRAG --|"regulates"|--> H2AX
    H2AX --|"indicates"|--> DNADamage
    UVRAG --|"associated with"|--> RAC1
    UVRAG --|"associated with"|--> APP
    
    Autophagy --|"clears"|--> APP
    UPS --|"degrades"|--> APP
    
    UVRAG --|"regulates"|--> Neurodegeneration
    UVRAG --|"regulates"|--> ALS
    UVRAG --|"associated with"|--> Parkinsons
    UVRAG --|"associated with"|--> MS
    UVRAG --|"regulates"|--> Aging
    
    DNADamage --|"contributes to"|--> Aging
    Aging --|"promotes"|--> Neurodegeneration
    
    style UVRAG fill:#006494
    style Autophagy fill:#1b5e20
    style UPS fill:#1b5e20
    style Proteasome fill:#1b5e20
    style PIK3C3 fill:#4a1a6b
    style ATG14 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style Neurodegeneration fill:#ef5350
    style Parkinsons fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Aging fill:#5d4400
    style DNADamage fill:#ef5350