protein

EGR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

418Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

Early Growth Response protein 1 - zinc finger transcription factor regulating immediate-early gene programs in neurodegeneration

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🔬 Protein Info

Gene Symbol	EGR1
Full Name	Early Growth Response 1
Aliases	Early Growth Response protein 1
Chromosome	5q31
Protein Type	Transcription Factor
Function	EGR1 is an immediate-early transcription factor that regulates neuronal plasticity, learning, memory, and response to neural activity.
Molecular Weight	59.8 kDa
Pathways	MAPK
UniProt ID	P18146
NCBI Gene ID	1958
Ensembl ID	ENSG00000120738
OMIM	129500
GeneCards	EGR1
Human Protein Atlas	EGR1
Associated Diseases	AD, ALI, Als, Alzheimer, ARM
Known Drugs/Compounds	metformin
Interactions	AGING, AKT, AKT3, ALZHEIMER, ALZHEIMER'S DISEASE, AND
KG Connections	416 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EGR1 — AlphaFold P18146 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

EGR1 Gene

gene · 704 words

→

EGR1 Protein

protein · 1108 words

→

Pathway Diagram

graph TD
    EGR1["EGR1"]
    EGR1 -->|"regulates"| FGF2["FGF2"]
    EGR1 -->|"participates in"| oxidative_stress["oxidative stress"]
    EGR1 -->|"participates in"| cardiac_hypertrophy["cardiac hypertrophy"]
    EGR1 -->|"target for"| Cancer["Cancer"]
    EGR1 -->|"target for"| Ms["Ms"]
    EGR1 -->|"target for"| Tumor["Tumor"]
    EGR1 -->|"activates"| Als["Als"]
    EGR1 -->|"activates"| Fibrosis["Fibrosis"]
    autophagy["autophagy"] -->|"activates"| EGR1
    MAPK_ERK["MAPK/ERK"] -->|"activates"| EGR1
    FGF2 -->|"activates"| EGR1
    TGFB1["TGFB1"] -->|"activates"| EGR1
    SOD1_downregulation["SOD1 downregulation"] -->|"activates"| EGR1
    IGF1R["IGF1R"] -->|"activates"| EGR1
    PTBP1["PTBP1"] -->|"activates"| EGR1
    TARDBP["TARDBP"] -->|"activates"| EGR1
    CALCOCO2["CALCOCO2"] -->|"activates"| EGR1
    PDGFRB["PDGFRB"] -->|"activates"| EGR1

Outgoing (267)

Target	Relation	Type	Str
FGF2	upregulates	gene	0.95
HNRNPA1	upregulates	gene	0.90
synaptic engram stabilization	regulates	mechanism	0.90
FGF2	regulates	protein	0.90
PRMT1	activates	gene	0.85
Proximal Tubule	expressed_in	cell_type	0.85
PRMT1	regulates	entity	0.85
oxidative stress	participates_in	phenotype	0.80
cardiac hypertrophy	participates_in	phenotype	0.80
Fibrosis	activates	disease	0.75
autophagy pathway	participates_in	pathway	0.70
Autophagy	activates	pathway	0.70
synaptic engram stabilization	associated_with	process	0.70
synaptic consolidation	regulates	process	0.70
neurons	expressed_in	cell_type	0.65
Retinopathy	activates	disease	0.65
Gastric Cancer	implicated_in	disease	0.65
ALS	activates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Inflammation	activates	disease	0.65
Carcinoma	activates	disease	0.65
ALS	degrades	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Cancer	associated_with	disease	0.65
Als	degrades	disease	0.65
Diabetes	activates	disease	0.65
Ms	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cardiovascular	activates	disease	0.65
Tumor	activates	disease	0.65
Tumor	inhibits	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Cardiac	regulates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Hypertension	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
neurotrophin signaling	participates_in	pathway	0.65
Ms	activates	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Anxiety	inhibits	disease	0.65

Incoming (151)

Source	Relation	Type	Str
autophagy	activates	pathway	0.95
Autophagy	activates	process	0.95
Autophagy Deficiency	downregulates	phenotype	0.90
FGF2	activates	protein	0.90
MAPK/ERK	activates	protein	0.90
Acute Kidney Injury	associated_with	disease	0.85
TGFB1	activates	protein	0.80
PRMT1	interacts_with	gene	0.80
SOD1 downregulation	activates	gene	0.70
IGF1R	activates	protein	0.64
HNRNPK	activates	gene	0.60
IGF1	activates	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
CXCL1	inhibits	gene	0.60
TARDBP	degrades	gene	0.60
AKT	interacts_with	entity	0.60
BANG	regulates	gene	0.60
STAT3	regulates	gene	0.60
TXNIP	activates	gene	0.60
SOCS3	activates	gene	0.60
YWHAZ	activates	gene	0.60
MYC	activates	gene	0.60
STAT3	activates	gene	0.60
PRMT1	encodes	gene	0.60
NR3C1	protects_against	gene	0.60
AXIN1	encodes	gene	0.60
HNF4A	encodes	gene	0.60
RHEB	encodes	gene	0.60
SOCS3	encodes	gene	0.60
RELA	encodes	gene	0.60
PPARG	encodes	gene	0.60
YY1	encodes	gene	0.60
NTRK2	activates	gene	0.60
YY1	regulates	gene	0.60
IL1B	inhibits	gene	0.60
FOSB	inhibits	gene	0.60
SOCS1	inhibits	gene	0.60
FOS	associated_with	gene	0.60
MYC	associated_with	gene	0.60
FOSB	associated_with	gene	0.60
CAMK2G	associated_with	gene	0.60
AND	activates	gene	0.60
PRMT1	associated_with	gene	0.60
PTBP1	activates	gene	0.60
TARDBP	activates	gene	0.60
CALCOCO2	activates	gene	0.60
PDGFRB	activates	gene	0.60
HNRNPA1	activates	gene	0.60
NDP52	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Do migratory animals encode specific spatial locations epigenetically or rely on

behavioral neuroscience | 2026-04-11 | 0 hypotheses

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

neuroscience | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The debate highlighted a fundamental uncertainty about whether transgenerational

closed · Rounds: 4 · Score: 0.70 · 2026-04-20

Related Research

Hypotheses and analyses mentioning EGR1 in their description or question text

No additional research found