protein

EGR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

421Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Early Growth Response protein 1 - zinc finger transcription factor regulating immediate-early gene programs in neurodegeneration

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🔬 Protein Info

Gene Symbol	EGR1
Full Name	Early Growth Response 1
Aliases	Early Growth Response protein 1
Chromosome	5q31
Protein Type	Transcription Factor
Function	EGR1 is an immediate-early transcription factor that regulates neuronal plasticity, learning, memory, and response to neural activity.
Molecular Weight	59.8 kDa
Pathways	MAPK
UniProt ID	P18146
NCBI Gene ID	1958
Ensembl ID	ENSG00000120738
OMIM	129500
GeneCards	EGR1
Human Protein Atlas	EGR1
Associated Diseases	AD, ALI, ALS, ARM, Alzheimer
Known Drugs/Compounds	metformin
Interactions	HNRNPK, NDP52, HNRNPA1, IGF1, FGF2, IGF1R
KG Connections	421 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EGR1 — AlphaFold P18146 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EGR1["EGR1"]
    EGR1 -->|"regulates"| FGF2["FGF2"]
    EGR1 -->|"participates in"| oxidative_stress["oxidative stress"]
    EGR1 -->|"participates in"| cardiac_hypertrophy["cardiac hypertrophy"]
    EGR1 -->|"target for"| Cancer["Cancer"]
    EGR1 -->|"target for"| Ms["Ms"]
    EGR1 -->|"target for"| Tumor["Tumor"]
    EGR1 -->|"activates"| Als["Als"]
    EGR1 -->|"activates"| Fibrosis["Fibrosis"]
    autophagy["autophagy"] -->|"activates"| EGR1
    MAPK_ERK["MAPK/ERK"] -->|"activates"| EGR1
    FGF2 -->|"activates"| EGR1
    TGFB1["TGFB1"] -->|"activates"| EGR1
    SOD1_downregulation["SOD1 downregulation"] -->|"activates"| EGR1
    IGF1R["IGF1R"] -->|"activates"| EGR1
    PTBP1["PTBP1"] -->|"activates"| EGR1
    TARDBP["TARDBP"] -->|"activates"| EGR1
    CALCOCO2["CALCOCO2"] -->|"activates"| EGR1
    PDGFRB["PDGFRB"] -->|"activates"| EGR1

Outgoing (269)

Target	Relation	Type	Str
FGF2	upregulates	gene	0.95
FGF2	regulates	protein	0.90
HNRNPA1	upregulates	gene	0.90
PRMT1	regulates	entity	0.85
Proximal Tubule	expressed_in	cell_type	0.85
PRMT1	activates	gene	0.85
cardiac hypertrophy	participates_in	phenotype	0.80
oxidative stress	participates_in	phenotype	0.80
Fibrosis	activates	disease	0.75
Autophagy	activates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
neurotrophin signaling	participates_in	pathway	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cardiac	regulates	disease	0.65
Ms	inhibits	disease	0.65
Cardiovascular	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Hypertension	expressed_in	disease	0.65
ALS	degrades	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	activates	disease	0.65
Anxiety	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	degrades	disease	0.65
Retinopathy	activates	disease	0.65
Diabetes	activates	disease	0.65
neurons	expressed_in	cell_type	0.65
Gastric Cancer	implicated_in	disease	0.65
PDGF_BB	regulates	protein	0.64
HNRNPK	activates	gene	0.60
NDP52	activates	gene	0.60

Incoming (152)

Source	Relation	Type	Str
Autophagy	activates	process	0.95
autophagy	activates	pathway	0.90
FGF2	activates	protein	0.90
Autophagy Deficiency	downregulates	phenotype	0.90
MAPK/ERK	activates	protein	0.90
Acute Kidney Injury	associated_with	disease	0.85
TGFB1	activates	protein	0.80
PRMT1	interacts_with	gene	0.80
SOD1 downregulation	activates	gene	0.70
IGF1R	activates	protein	0.64
PRMT1	associated_with	gene	0.60
PTBP1	activates	gene	0.60
TARDBP	activates	gene	0.60
CALCOCO2	activates	gene	0.60
PDGFRB	activates	gene	0.60
HNRNPA1	activates	gene	0.60
NDP52	activates	gene	0.60
HNRNPK	activates	gene	0.60
IGF1	activates	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
CXCL1	inhibits	gene	0.60
TARDBP	degrades	gene	0.60
GATA2	protects_against	gene	0.60
TNF	regulates	gene	0.60
GAPDH	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
CEBPB	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
CXCL12	associated_with	gene	0.60
AKT	interacts_with	entity	0.60
ATF3	protects_against	entity	0.60
CEBPA	protects_against	entity	0.60
PPARG	protects_against	gene	0.60
NFKB1	protects_against	gene	0.60
PTBP1	degrades	gene	0.60
BANG	regulates	gene	0.60
STAT3	regulates	gene	0.60
ESR1	regulates	gene	0.60
TXNIP	activates	gene	0.60
SOCS3	activates	gene	0.60
YWHAZ	activates	gene	0.60
MYC	activates	gene	0.60
STAT3	activates	gene	0.60
MAPK1	activates	gene	0.60
CREB1	activates	gene	0.60
NTRK3	activates	gene	0.60
AXIN1	activates	gene	0.60
RHEB	activates	gene	0.60
GAD1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EGR1

Understanding Entity Pages

Summary

Wiki Pages (21)

EGR1 Gene

Epigenetic Dysregulation in Neurodegeneration

CREB Signaling in Neurodegeneration

FGF23 — Fibroblast Growth Factor 23

mossy-cells-dentate-gyrus

Activity-Dependent Synaptic Plasticity in Neurodegeneration

H3F3B Gene — H3.3 Histone B

Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis and Enhancement

EIF4EBP1 — Eukaryotic Translation Initiation Factor 4E Binding Protein 1

Schwann Cells

Accessory Nucleus Neurons (Edinger-Westphal Nucleus)

DNA Damage Response in Alzheimer's Disease

NEUROD2 Gene

HNRNPK Gene

CHD1 Protein

EGR4

TET3 Gene

Synaptic Plasticity Dysfunction in 4R-Tauopathies

FGF-2 Protein (bFGF)