Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about edaravone: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Name | edaravone |
| Related Diseases | Amyotrophic Lateral Sclerosis |
| Related Pathways | Oxidative Damage |
Knowledge base pages for this entity
flowchart TD
edaravone["edaravone"]
Oxidative_Stress["Oxidative Stress"]
edaravone -->|"inhibits"| Oxidative_Stress
Oxidative_Damage("Oxidative Damage")
edaravone -->|"associated with"| Oxidative_Damage
Amyotrophic_Lateral_Sclerosis("Amyotrophic Lateral Sclerosis")
edaravone -->|"treats"| Amyotrophic_Lateral_Sclerosis
Mitochondrial_Function["Mitochondrial Function"]
edaravone -->|"associated with"| Mitochondrial_Function
Neuroinflammation("Neuroinflammation")
edaravone -->|"modulates"| Neuroinflammation
ALS("ALS")
edaravone -->|"treats"| ALS
style edaravone fill:#0d47a1,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Oxidative Stress | inhibits | process | 0.90 |
| Oxidative Damage | associated_with | mechanism | 0.90 |
| Amyotrophic Lateral Sclerosis | treats | disease | 0.80 |
| Mitochondrial Function | associated_with | process | 0.80 |
| Neuroinflammation | modulates | process | 0.80 |
| OXIDATIVE_STRESS | treats | process | 0.78 |
| NEURON | activates | cell_type | 0.70 |
| SIRT1 | treats | gene | 0.65 |
| APP | treats | gene | 0.65 |
| OLIGODENDROCYTE | degrades | cell_type | 0.65 |
| NEURON | associated_with | cell_type | 0.50 |
| RILUZOLE | associated_with | drug | 0.45 |
| SIRT1 | associated_with | gene | 0.45 |
| NRF2 | associated_with | gene | 0.45 |
| GPX4 | associated_with | gene | 0.45 |
| MBP | associated_with | gene | 0.45 |
| TREM2 | associated_with | gene | 0.45 |
| TLR4 | associated_with | gene | 0.45 |
| APP | associated_with | gene | 0.45 |
| SOD1 | associated_with | gene | 0.45 |
| KEAP1 | associated_with | gene | 0.45 |
| ALS | associated_with | disease | 0.45 |
| MINOCYCLINE | associated_with | drug | 0.45 |
| GLUTAMATE | associated_with | phenotype | 0.45 |
| APOPTOSIS | associated_with | phenotype | 0.45 |
| MAPK | associated_with | gene | 0.45 |
| STROKE | associated_with | disease | 0.45 |
| RILUZOLE | therapeutic_target | drug | 0.35 |
| MINOCYCLINE | inhibits | drug | 0.35 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALS | treats | disease | 0.65 |
| MINOCYCLINE | associated_with | drug | 0.45 |
| ALS | associated_with | disease | 0.45 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | disease | 0.45 |
| NEUROGENESIS | associated_with | phenotype | 0.45 |
| OLIGODENDROCYTE | associated_with | cell_type | 0.45 |
| OXIDATIVE STRESS | associated_with | phenotype | 0.45 |
| CYTOKINES | inhibits | protein | 0.35 |
| ALS | therapeutic_target | disease | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||