concept

OLIGODENDROCYTE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OLIGODENDROCYTE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1555Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

OLIGODENDROCYTE is a concept in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, Aging, Als. Connected to 369 entities in the SciDEX knowledge graph.

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Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Oligodendrocyte Lineage in Multiple System Atrophy

cell · 675 words

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Pathway Diagram

graph TD
    OLIGODENDROCYTE["OLIGODENDROCYTE"]
    OLIGODENDROCYTE -->|"implicated in"| Alzheimer_s_disease["Alzheimer's disease"]
    OLIGODENDROCYTE -->|"regulates"| Myelin["Myelin"]
    OLIGODENDROCYTE -->|"regulates"| Aging["Aging"]
    OLIGODENDROCYTE -->|"activates"| Inflammation["Inflammation"]
    OLIGODENDROCYTE -->|"inhibits"| ALS["ALS"]
    OLIGODENDROCYTE -->|"inhibits"| Autoimmune["Autoimmune"]
    OLIGODENDROCYTE -->|"inhibits"| GPR37["GPR37"]
    OLIGODENDROCYTE -->|"inhibits"| Myelination["Myelination"]
    OLIGODENDROCYTE -->|"activates"| INFLAMMATION["INFLAMMATION"]
    MLKL["MLKL"] -->|"activates"| OLIGODENDROCYTE
    OPTN["OPTN"] -.protects against.-> OLIGODENDROCYTE
    AQUAPORIN_4["AQUAPORIN-4"] -.biomarker for.-> OLIGODENDROCYTE
    MYELIN["MYELIN"] -.biomarker for.-> OLIGODENDROCYTE
    MOG["MOG"] -.biomarker for.-> OLIGODENDROCYTE
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| OLIGODENDROCYTE
    BANG["BANG"] -->|"activates"| OLIGODENDROCYTE
    COMPLEMENT["COMPLEMENT"] -->|"causes"| OLIGODENDROCYTE
    AQP4["AQP4"] -->|"causes"| OLIGODENDROCYTE

Outgoing (619)

Target	Relation	Type	Str
Alzheimer'S Disease	involved_in	disease	0.95
Myelin Degeneration	contributes_to	phenotype	0.95
Myelin	associated_with	structure	0.95
Neuroinflammation	associated_with	process	0.90
neuroinflammation	drives	process	0.90
neurodegeneration	drives	process	0.90
Neurodegeneration	associated_with	process	0.90
Parkinson'S Disease	involved_in	disease	0.90
Active Lesion Rim	involved_in	phenotype	0.90
Excitotoxicity	mediates	process	0.90
Neuroinflammation	mediates	process	0.90
Remyelination	involved_in	process	0.90
MICROGLIA	activates	gene	0.90
Multiple Sclerosis	therapeutic_target	disease	0.85
Inflammation	activates	disease	0.85
Als	activates	disease	0.85
Axonal Myelination	involved_in	process	0.85
Multiple Sclerosis	associated_with	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Neuroinflammation	therapeutic_target	disease	0.85
Inflammatory Genes	upregulates	process	0.80
Myelin Sulfatide	produces	molecule	0.80
MYELIN	associated_with	gene	0.80
ASTROCYTE	activates	gene	0.80
Inflammation	associated_with	disease	0.75
Neurodegeneration	activates	disease	0.75
Alzheimer's disease	implicated_in	disease	0.75
Autoimmune	inhibits	disease	0.75
Als	therapeutic_target	disease	0.75
Dementia	inhibits	disease	0.75
Autoimmune	activates	disease	0.75
Alzheimer	inhibits	disease	0.75
Stroke	therapeutic_target	disease	0.75
OLIG2	stabilizes	gene	0.70
NEUROINFLAMMATION	therapeutic_target	gene	0.70
SENESCENCE	treats	phenotype	0.70
ASTROCYTES	associated_with	gene	0.70
MBP	activates	gene	0.70
Myelin	regulates	entity	0.70
Myelin	activates	entity	0.70
Apoptosis	activates	pathway	0.70
Mtor	inhibits	pathway	0.70
Pi3K/Akt	inhibits	pathway	0.70
Wnt	inhibits	pathway	0.70
ALZHEIMER	inhibits	gene	0.70
AKT	inhibits	gene	0.70
MTOR	inhibits	gene	0.70
DEMENTIA	inhibits	gene	0.70
P53	inhibits	gene	0.70
NEURON	inhibits	gene	0.70

Incoming (936)

Source	Relation	Type	Str
NEURODEGENERATION	associated_with	gene	1.00
ASTROCYTES	associated_with	gene	0.98
MICROGLIA	associated_with	gene	0.98
Ferroptosis	expressed_in	process	0.90
Multiple Sclerosis	causes	disease	0.90
Multiple Sclerosis	downregulates	disease	0.90
ALZHEIMER'S DISEASE	associated_with	gene	0.90
COMPLEMENT CASCADE	causes	entity	0.90
MYELIN	activates	gene	0.90
APOE4	expressed_in	gene	0.88
IGF1	promotes	protein	0.88
Microglia	interacts_with	cell_type	0.85
Cholesterol Metabolism	expressed_in	pathway	0.85
Α-SYNUCLEIN	expressed_in	protein	0.80
MYELIN	associated_with	gene	0.75
SERPINA3N	expressed_in	gene	0.75
OPC	associated_with	cell_type	0.75
NEUROINFLAMMATION	associated_with	gene	0.74
TAU	associated_with	protein	0.74
HDAC3	regulates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
ASTROCYTES	regulates	cell_type	0.70
HDAC3	inhibits	gene	0.70
HDAC3	treats	gene	0.70
ASTROCYTE	regulates	cell_type	0.70
HK2	activates	gene	0.70
NEURODEGENERATION	causes	disease	0.70
ASTROCYTE	associated_with	gene	0.70
HK2	inhibits	gene	0.70
MICROGLIAL ACTIVATION	activates	phenotype	0.70
MICROGLIAL ACTIVATION	stabilizes	phenotype	0.70
INFLAMMATION	activates	gene	0.70
MOG	activates	gene	0.70
ASTROCYTE	activates	cell_type	0.70
MYELIN	inhibits	gene	0.70
BMP4	produces	gene	0.70
MLKL	activates	protein	0.70
OPTN	protects_against	protein	0.70
JUN	associated_with	gene	0.66
APP	associated_with	gene	0.66
APOPTOSIS	associated_with	gene	0.66
AMYLOID	associated_with	gene	0.66
GLUTAMATERGIC	expressed_in	cell_type	0.65
NRF2	inhibits	gene	0.65
APOE2	activates	gene	0.65
HDAC3	associated_with	gene	0.65
MICROGLIA	mediates	cell_type	0.65
IGF1	interacts_with	gene	0.65
MBP	associated_with	gene	0.65
BCL2	co_discussed	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 18 hypotheses Top: 0.825

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.90 · 2026-04-03