concept

HYPOTHALAMUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HYPOTHALAMUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

451Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

HYPOTHALAMUS is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, causes. Associated with ALZHEIMER'S DISEASE, STROKE. Connected to 21 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HYPOTHALAMUS
Summary	Page for Hypothalamus
Key Genes/Proteins	AMPK, TAU
Related Diseases	ALZHEIMER'S DISEASE, METABOLIC SYNDROME

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HYPOTHALAMUS["<b>HYPOTHALAMUS</b>"]
    HYPOTHALAMUS -->|"regulates"| Circadian_Rhythm["Circadian Rhythm"]
    HYPOTHALAMUS -->|"mediates"| RAPHE["RAPHE"]
    HYPOTHALAMUS -->|"mediates"| THALAMUS["THALAMUS"]
    HYPOTHALAMUS -->|"causes"| STROKE["STROKE"]
    CORTISOL["CORTISOL"] -->|"inhibits"| HYPOTHALAMUS
    APOPTOSIS["APOPTOSIS"] -->|"causes"| HYPOTHALAMUS
    GLUTAMATERGIC["GLUTAMATERGIC"] -->|"causes"| HYPOTHALAMUS
    CLOCK["CLOCK"] -->|"expressed in"| HYPOTHALAMUS
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"] -->|"expressed in"| HYPOTHALAMUS
    CANCER["CANCER"] -->|"expressed in"| HYPOTHALAMUS
    JUN["JUN"] -->|"expressed in"| HYPOTHALAMUS
    VDR["VDR"] -->|"expressed in"| HYPOTHALAMUS
    POMC["POMC"] -->|"expressed in"| HYPOTHALAMUS
    CRH["CRH"] -->|"expressed in"| HYPOTHALAMUS
    NPY["NPY"] -->|"expressed in"| HYPOTHALAMUS
    ARC["ARC"] -->|"expressed in"| HYPOTHALAMUS

Outgoing (127)

Target	Relation	Type	Str
CIRCADIAN RHYTHM	regulates	entity	0.95
NEURON	activates	cell_type	0.95
NEURON	regulates	cell_type	0.80
SPINAL CORD	regulates	brain_region	0.70
THALAMUS	regulates	brain_region	0.65
NEURON	causes	cell_type	0.65
NEURONS	causes	cell_type	0.65
THALAMUS	increases	brain_region	0.65
THALAMUS	stabilizes	brain_region	0.65
TAU	phosphorylates	gene	0.65
METABOLIC SYNDROME	protects_against	disease	0.65
THALAMUS	associated_with	brain_region	0.60
RAPHE	mediates	brain_region	0.60
THALAMUS	mediates	brain_region	0.60
THALAMUS	causes	brain_region	0.60
STROKE	causes	disease	0.60
THALAMUS	expressed_in	brain_region	0.60
THALAMUS	interacts_with	brain_region	0.60
NEURON	expressed_in	cell_type	0.60
NEURONS	expressed_in	cell_type	0.60
THALAMUS	contributes_to	brain_region	0.60
NEURONS	activates	cell_type	0.60
RAPHE	impairs	brain_region	0.60
NEURONS	regulates	cell_type	0.60
THALAMUS	inhibits	brain_region	0.60
THALAMUS	activates	brain_region	0.60
STING	expressed_in	gene	0.60
SPINAL CORD	implicated_in	brain_region	0.60
AMPK	implicated_in	gene	0.55
AMPK	participates_in	gene	0.55
THALAMUS	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
SUBSTANTIA NIGRA	co_discussed	entity	0.50
NEURON	implicated_in	cell_type	0.50
DOPAMINE	associated_with	concept	0.50
NUCLEUS	inhibits	concept	0.50
HCRT	associated_with	concept	0.50
ENDOPLASMIC RETICULUM STRESS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
HCRT	inhibits	concept	0.50
HCRT	activates	concept	0.50
AMYGDALA	expressed_in	concept	0.50
CEREBRAL CORTEX	expressed_in	concept	0.50
CEREBELLUM	expressed_in	concept	0.50
Infection	activates	disease	0.50
CYTOKINES	associated_with	phenotype	0.50
NLRP3	associated_with	gene	0.50
GABA	associated_with	phenotype	0.45
NEURON	associated_with	cell_type	0.45

Incoming (324)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
CLOCK	expressed_in	entity	0.80
BMAL1	expressed_in	entity	0.80
AMPK	activates	gene	0.80
HTR1A	increases	gene	0.65
SMAD4	regulates	gene	0.65
OBESITY	regulates	disease	0.65
MFSD2A	activates	gene	0.65
CORTISOL	inhibits	protein	0.64
AMYLOID	associated_with	protein	0.64
GLUTAMATERGIC	causes	cell_type	0.60
BDNF	expressed_in	gene	0.58
JUN	associated_with	gene	0.56
AMPK	associated_with	gene	0.56
ASTROCYTES	associated_with	cell_type	0.56
PARKINSON'S DISEASE	associated_with	disease	0.56
TAU	associated_with	protein	0.56
APP	associated_with	gene	0.56
MICROGLIA	associated_with	cell_type	0.56
HUNTINGTIN	expressed_in	protein	0.55
HUNTINGTIN	implicated_in	protein	0.55
CIRCADIAN	co_discussed	entity	0.50
DOPAMINERGIC	co_discussed	entity	0.50
HIPPOCAMPUS	co_discussed	entity	0.50
GABA	co_discussed	entity	0.50
HIPPOCAMPUS	expressed_in	brain_region	0.50
CEREBRAL CORTEX	expressed_in	brain_region	0.50
CLOCK	regulates	gene	0.50
Circadian Rhythm	regulates	process	0.50
NEURONS	associated_with	concept	0.50
Substantia Nigra	associated_with	entity	0.50
DOPAMINERGIC	associated_with	concept	0.50
NEURONS	regulates	concept	0.50
HTR1A	activates	gene	0.50
Hippocampus	associated_with	entity	0.50
GABA	regulates	gene	0.50
ST8SIA1	associated_with	concept	0.50
acetylcholine	inhibits	disease	0.50
STROKE	inhibits	gene	0.50
apoptosis	inhibits	process	0.50
Neuron	inhibits	cell_type	0.50
NEURONS	inhibits	concept	0.50
Astrocytes	associated_with	cell_type	0.50
GAIN	interacts_with	gene	0.50
Metabolic Syndrome	interacts_with	disease	0.50
JNK1	activates	gene	0.50
inflammation	activates	pathway	0.50
oxidative stress	activates	phenotype	0.50
Neuroinflammation	associated_with	process	0.50
Neurodegeneration	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HYPOTHALAMUS

Understanding Entity Pages

Summary

Wiki Pages (21)

Hypothalamus

cbs-psp-daily-action-plan

Sleep and Circadian Dysfunction in Alzheimer's Disease

Neurons — Cell Type Hierarchy

CLCN10 — Chloride Voltage-Gated Channel 10

Circadian Rhythm in Neurodegeneration

cerebral-cortical-vasal-neurons

omega-3-fatty-acids-neurodegeneration

Spinal Cord Dorsal Horn Neurons

Paraventricular Hypothalamic Nucleus (PVN) Neurons

vitamin-d-therapy-neurodegeneration

Locus Coeruleus Alpha Neurons

NPAS3 Gene

Curcumin for Neurodegeneration

Histamine

Fatal Familial Insomnia

Pedunculopontine Nucleus Cholinergic Neurons in Neurodegeneration

Idorsia Pharmaceuticals Ltd.

Gut-Brain Axis in Neurodegeneration