Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about OXIDATIVE DAMAGE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | OXIDATIVE DAMAGE |
Knowledge base pages for this entity
graph TD
OXIDATIVE_DAMAGE["OXIDATIVE DAMAGE"]
OXIDATIVE_DAMAGE -->|"causes"| Alzheimer_s_Disease["Alzheimer's Disease"]
OXIDATIVE_DAMAGE -->|"targets"| Cellular_Components["Cellular Components"]
OXIDATIVE_DAMAGE -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
OXIDATIVE_DAMAGE -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
OXIDATIVE_DAMAGE -->|"activates"| amyloid_beta_peptide["amyloid beta peptide"]
OXIDATIVE_DAMAGE -->|"inhibits"| mitophagy["mitophagy"]
OXIDATIVE_DAMAGE -->|"activates"| amyloid_beta["amyloid beta"]
LUZP1["LUZP1"] -.prevents.-> OXIDATIVE_DAMAGE
Antioxidant_Systems["Antioxidant Systems"] -.protects against.-> OXIDATIVE_DAMAGE
AGTR1["AGTR1"] -->|"mediates"| OXIDATIVE_DAMAGE
reactive_oxygen_species["reactive oxygen species"] -->|"activates"| OXIDATIVE_DAMAGE
excess_intracellular_calcium["excess intracellular calcium"] -->|"activates"| OXIDATIVE_DAMAGE| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | causes | disease | 0.90 |
| ALS | biomarker_for | disease | 0.90 |
| Metabolic Enzymes | associated_with | protein | 0.85 |
| Cellular Components | targets | mechanism | 0.80 |
| Neurodegeneration | contributes_to | process | 0.80 |
| amyloid beta peptide | activates | protein | 0.70 |
| amyloid beta | activates | protein | 0.70 |
| Alzheimer's disease | causes | disease | 0.70 |
| Alzheimer's disease | activates | disease | 0.70 |
| mitophagy | inhibits | process | 0.70 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LUZP1 | prevents | protein | 0.90 |
| Antioxidant Systems | protects_against | pathway | 0.90 |
| AGTR1 | mediates | gene | 0.90 |
| edaravone | associated_with | drug | 0.90 |
| disrupted circadian signaling | associated_with | process | 0.87 |
| mitochondrial dynamics | suppresses | process | 0.85 |
| Ferroptosis | causes | process | 0.85 |
| Pbt434 | associated_with | compound | 0.80 |
| TAZ | modulates | gene | 0.80 |
| Nanotechnology | treats | process | 0.75 |
| reactive oxygen species | activates | process | 0.70 |
| excess intracellular calcium | activates | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||