concept

MITOCHONDRIAL DYNAMICS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MITOCHONDRIAL DYNAMICS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

126Connections

0Hypotheses

0Analyses

30Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MITOCHONDRIAL DYNAMICS
Linked Hypotheses	10 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MITOCHONDRIAL_DYNAMICS["MITOCHONDRIAL DYNAMICS"]
    MITOCHONDRIAL_DYNAMICS -->|"involved_in"| Glaucomatous_Neuropathy["Glaucomatous Neuropathy"]
    MITOCHONDRIAL_DYNAMICS -->|"involved_in"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    MITOCHONDRIAL_DYNAMICS -->|"interacts"| Mitochondrial_Autophagy["Mitochondrial Autophagy"]
    MITOCHONDRIAL_DYNAMICS -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    MITOCHONDRIAL_DYNAMICS -->|"interacts"| mitophagy["mitophagy"]
    MITOCHONDRIAL_DYNAMICS -->|"regulates"| Senescence["Senescence"]
    MITOCHONDRIAL_DYNAMICS -->|"causes"| Cancer["Cancer"]
    MITOCHONDRIAL_DYNAMICS -->|"regulates"| Mitochondrial_Bioenergetics["Mitochondrial Bioenergetics"]
    PGAM5["PGAM5"] -->|"regulates"| MITOCHONDRIAL_DYNAMICS
    Metformin["Metformin"] -->|"modulates"| MITOCHONDRIAL_DYNAMICS
    AMPK_Drp1_Signaling_Pathway["AMPK/Drp1 Signaling Pathway"] -->|"regulates"| MITOCHONDRIAL_DYNAMICS
    GJA1_20K["GJA1-20K"] -->|"involved_in"| MITOCHONDRIAL_DYNAMICS
    mitophagy -->|"modulates"| MITOCHONDRIAL_DYNAMICS
    SIRT1["SIRT1"] -->|"regulates"| MITOCHONDRIAL_DYNAMICS
    MIRO1["MIRO1"] -->|"regulates"| MITOCHONDRIAL_DYNAMICS
    METFORMIN["METFORMIN"] -->|"modulates"| MITOCHONDRIAL_DYNAMICS

Outgoing (30)

Target	Relation	Type	Str
Glaucomatous Neuropathy	involved_in	disease	0.92
Alzheimer'S Disease	involved_in	disease	0.90
neurons	active_in	cell_type	0.90
Mitochondrial Autophagy	interacts_with	process	0.88
Mitochondrial Bioenergetics	regulates	process	0.85
Mitochondrial Bioenergetics	involved_in	process	0.85
Circadian Entrainment	contributes_to	process	0.85
oxidative damage	suppresses	process	0.85
Alzheimer's Disease	involved_in	disease	0.85
mitophagy	interacts_with	process	0.85
Senescence	regulates	process	0.85
Cancer	causes	disease	0.85
Redox Homeostasis	associated_with	process	0.80
Redox Homeostasis	contributes_to	process	0.80
Related Disorders	causes	disease	0.80
molybdenum cofactor deficiency	disrupted_in	disease	0.80
Brain Maturation	contributes_to	process	0.80
neural stem cells	active_in	cell_type	0.80
Aging	involved_in	phenotype	0.75
cellular apoptosis	regulates	process	0.70
unfolded protein response	crosstalk_with	pathway	0.70
hippocampus	active_in	brain_region	0.70
thalamus	active_in	brain_region	0.60
hypothalamus	active_in	brain_region	0.60
cerebellum	active_in	brain_region	0.60
microglia	active_in	cell_type	0.60
endothelial cells	active_in	cell_type	0.60
cortex	active_in	brain_region	0.60
synaptic plasticity	crosstalk_with	pathway	0.60
oxidative stress response	crosstalk_with	pathway	0.60

Incoming (96)

Source	Relation	Type	Str
DRP1	involved_in	protein	0.95
OPA1	involved_in	protein	0.95
MFN2	involved_in	protein	0.95
MT1	regulates	receptor	0.95
MFN2	regulates	protein	0.95
PGAM5	regulates	protein	0.95
Metformin	modulates	drug	0.90
AMPK/Drp1 Signaling Pathway	regulates	pathway	0.90
DRP1	participates_in	gene	0.90
DRP1	regulates	protein	0.90
OPA1	participates_in	gene	0.90
Cytoskeleton Disruption	associated_with	mechanism	0.90
ROS	participates_in	gene	0.90
Acetylated Microtubules	regulates	structure	0.88
SIRT1	regulates	protein	0.85
MIRO1	regulates	protein	0.85
SNCA	regulates	protein	0.85
Intercellular Mitochondrial Transfer	interacts_with	process	0.85
Mitochondria-Lysosome Contacts	regulates	mechanism	0.85
serotonin signaling	regulates	pathway	0.85
MAMs	regulates	process	0.85
Chemerin	regulates	protein	0.85
BDNF	regulates	gene	0.85
GJA1-20K	involved_in	protein	0.85
mitophagy	modulates	process	0.85
neurodegeneration	involves	disease	0.80
AMPK/Drp1 signaling pathway	mediates	pathway	0.80
Honokiol	modulates	compound	0.80
ApoE4	modulates	protein	0.80
PINK1	regulates	gene	0.80
Amyloid Aggregates	correlates_with	compound	0.80
MFN2	participates_in	gene	0.80
DNM1L	regulates	gene	0.80
BDNF	associated_with	gene	0.80
DRP1	mediates	protein	0.80
APOE	affects	gene	0.80
METFORMIN	modulates	drug	0.80
AMPK	participates_in	gene	0.80
diabetes	involves	disease	0.80
Alpha-Synuclein	regulates	protein	0.80
GJA1-20K	regulates	protein	0.80
P62	participates_in	gene	0.70
PI3K	participates_in	gene	0.70
PPARGC1A	participates_in	gene	0.70
TH	participates_in	gene	0.70
APP	participates_in	gene	0.70
PINK1	participates_in	gene	0.70
MFN1	participates_in	gene	0.70
HDAC3	participates_in	gene	0.70
BDNF	participates_in	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MITOCHONDRIAL DYNAMICS

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Parthanatos in Neurodegeneration

Neuroresilience Mechanisms and Evidence

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

NRF2 Oxidative Stress Pathway

coq10-neurodegeneration

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

oxidative-stress-comparison

APOC4 — Apolipoprotein C-IV

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

ftd-tdp-pathology