SPP1-Integrin Competitive Inhibition
🧪 Overview
RGD-based competitive peptide inhibitors targeting αvβ3 and αvβ5 integrins to block SPP1-mediated microglial adhesion and migration toward synapses
Debate provenance: derived from debate `sess_SDA-2026-04-15-gap-pubmed-20260406-062118-e3613755` on question: What molecular mechanisms mediate SPP1-induced microglial phagocytic activation and synaptic targeting?. Consensus signal: domain_expert, skeptic, synthesizer, theorist discussed the mechanism terms Competitive, ITGAV, Inhibition, RGD, SPP1, SPP1-Integrin, inhibition, microglial. Novelty signal: skeptic-discussed-with-qualified-concession.
🧬 Mechanism
Auto-built from this analysis's top knowledge-graph edges.
graph TD
SPP1["SPP1"] -->|binds to| ITGAV["ITGAV"]
ITGAV_inhibition["ITGAV_inhibition"] -->|prevents| synaptic_engulfment["synaptic_engulfment"]
ITGAV_1["ITGAV"] -->|regulates| microglial_adhesion["microglial_adhesion"]
style SPP1 fill:#4fc3f7,stroke:#333,color:#000
style ITGAV fill:#4fc3f7,stroke:#333,color:#000
style ITGAV_inhibition fill:#4fc3f7,stroke:#333,color:#000
style synaptic_engulfment fill:#4fc3f7,stroke:#333,color:#000
style ITGAV_1 fill:#4fc3f7,stroke:#333,color:#000
style microglial_adhesion fill:#4fc3f7,stroke:#333,color:#000⚖️ Evidence
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — ITGAV
No curated PDB or AlphaFold mapping for ITGAV yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for ITGAV.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
📊 Market Indicators
💾 Resource Usage
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_round_mining
| source | v1_phase_c_backfill |
| origin_type | debate_round_mining |
| _schema_version | 1 |