gene

RHOA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RHOA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

361Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

RHOA is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with ALS, Aging, Als. Connected to 157 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RHOA
Full Name	Ras Homolog Family Member A
Chromosome	3p21.31
Function	encodes a small GTP-binding protein that functions as a molecular switch, cycling between an active GTP-bound state and an inactive GDP-bound state.
Molecular Weight	~22 kDa
Amino Acids	191 aa
Pathways	Akt, Angiogenesis, Apoptosis, Complement, Egfr Signaling
UniProt ID	[P61586](https://www.uniprot.org/uniprotkb/P61586/entry)
Ensembl ID	ENSG00000167553
GeneCards	RHOA
Human Protein Atlas	RHOA
Associated Diseases	Alzheimer, Dementia, Lung Cancer, Ms, TUMOR
Interactions	ARF1, ROCK1, BMAL1, APP, CDC42, TP53
KG Connections	357 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RHOA["RHOA"] -->|"activates"| Aging["Aging"]
    RHOA["RHOA"] -->|"activates"| Ms["Ms"]
    RHOA["RHOA"] -->|"activates"| Als["Als"]
    RHOA["RHOA"] -->|"activates"| Osteoporosis["Osteoporosis"]
    RHOA["RHOA"] -->|"regulates"| Alzheimer["Alzheimer"]
    RHOA["RHOA"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    EPHB4["EPHB4"] -->|"activates"| RHOA["RHOA"]
    ARF1["ARF1"] -.->|"inhibits"| RHOA["RHOA"]
    APP_PS1["APP/PS1"] -->|"regulates"| RHOA["RHOA"]
    P62["P62"] -->|"regulates"| RHOA["RHOA"]
    style RHOA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (246)

Target	Relation	Type	Str
osteoblast	involved_in	cell_type	0.75
Als	activates	disease	0.75
Als	inhibits	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
neurodevelopmental disorders	implicated_in	disease	0.70
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Osteoporosis	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Aging	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Autism	expressed_in	disease	0.65
Fibrosis	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Lymphoma	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Fibrosis	inhibits	disease	0.65
Nephropathy	activates	disease	0.65
Gastric Cancer	activates	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neuropathy	activates	disease	0.65
Dementia	therapeutic_target	disease	0.65
Autism	activates	disease	0.65
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
ALS	inhibits	disease	0.65
Dementia	causes	disease	0.65
Alzheimer	causes	disease	0.65
Vascular Dementia	causes	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	activates	disease	0.65

Incoming (115)

Source	Relation	Type	Str
Icariin	upregulates	compound	0.85
EPHB4	regulates	gene	0.80
EPHB4	activates	gene	0.60
ARF1	inhibits	gene	0.60
P62	regulates	gene	0.60
ROCK1	activates	gene	0.60
LAMP1	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
AKT	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
MAPK1	associated_with	gene	0.60
BNIP3	regulates	gene	0.60
PI3K	activates	gene	0.60
PIEZO1	activates	gene	0.60
RAC1	inhibits	gene	0.60
LAMP1	inhibits	gene	0.60
HDAC6	inhibits	gene	0.60
PIK3CA	interacts_with	gene	0.60
RANKINGS	interacts_with	gene	0.60
RAC1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
CBL	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
BCL2L1	associated_with	gene	0.60
MAP2K1	associated_with	gene	0.60
ANGPT1	associated_with	gene	0.60
APP	regulates	gene	0.60
TFEB	regulates	gene	0.60
TP53	activates	gene	0.60
PKC	activates	gene	0.60
BMAL1	inhibits	gene	0.60
OVERVIEW	regulates	gene	0.60
EPHB4	expressed_in	entity	0.60
ARF1	activates	entity	0.60
GIT1	activates	gene	0.60
EGFR	associated_with	gene	0.60
APP	inhibits	gene	0.60
CDC42	inhibits	gene	0.60
NOS3	regulates	gene	0.60
IGF1	regulates	gene	0.60
PIK3R1	regulates	gene	0.60
MAPK14	regulates	gene	0.60
PI3K	regulates	gene	0.60
SRC	regulates	gene	0.60
HRAS	regulates	gene	0.60
AKT	regulates	gene	0.60
ESR1	regulates	gene	0.60
MMP9	regulates	gene	0.60
BDNF	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RHOA

Understanding Entity Pages

Summary

Wiki Pages (21)

RHOA Gene — Ras Homolog Family Member A

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

dendritic-spines

rankings

KRIT1 — Krev Interaction Trapped 1 (CCM1)

TGF-β Signaling in Parkinson's Disease

EPHA7 Gene

Tunneling Nanotubes in Neurodegeneration

EPHA6 — Ephrin Type-A Receptor 6

BDNF/Neurotrophin Signaling in Neurodegeneration

WNT4 Gene

WNT7A Gene

ROCK1 Gene

EPHA8 Gene

RRAS3 — Related RAS Virus (R-Ras) Family Member 3

EPHA3 Gene

Actin Cytoskeleton Dynamics in Neurodegeneration

EPHA4 Gene

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1