| Gene Symbol | DGAT1 |
| Full Name | Diacylglycerol O-Acyltransferase 1 |
| Chromosome | 8q24.3 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | Small molecule inhibitor of triglyceride synthesis enzyme |
| Mechanism of Action | Small molecule inhibitor of triglyceride synthesis enzyme |
| Primary Expression | multiple cell types within the CNS: |
| Druggability | Low (0.41) |
| Clinical Stage | Phase III |
| Molecular Weight | 53 kDa |
| Amino Acids | 460 aa |
| Exons | 17 |
| Pathways | Astrocyte reactivity signaling |
| UniProt ID | Q3KQR6 |
| Ensembl ID | ENSG00000185088 |
| OMIM | 604035 |
| GeneCards | DGAT1 |
| Human Protein Atlas | DGAT1 |
| Associated Diseases | glioblastoma, neurodegeneration, stroke |
| Known Drugs/Compounds | Pradigastat |
| Interactions | AMPK, AND, APOA1, APP, ATGL, C3 |
| SciDEX Target | View Target Profile (2 clinical trials) |
| SciDEX Hypotheses | Astrocyte-Specific DGAT1 Inhibition to Prevent Lip Lipid Droplet Dynamics as Therapeutic Lever |
| KG Connections | 172 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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