gene

VDAC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VDAC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

507Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for VDAC1 — Voltage Dependent Anion Channel 1

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🧬 Gene Info

Gene Symbol	VDAC1
Full Name	Voltage Dependent Anion Channel 1
Chromosome	5q31
Protein Type	Channel
Function	VDAC1 encodes the voltage-dependent anion channel 1, also known as porin.
Primary Expression	Brain, Heart, Liver, Kidney
Molecular Weight	31 kDa
Pathways	Apoptosis, Autophagy, Er Stress, Glycolysis, Mitochondrial Function
UniProt ID	P21796
NCBI Gene ID	7416
Ensembl ID	ENSG00000110833
GeneCards	VDAC1
Human Protein Atlas	VDAC1
Symbol [@thinnes2014] VDAC1 [@giorgio2018] Full Name	Voltage Dependent Anion Channel 1
Associated Diseases	ALS, ALZHEIMER, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Cancer
Interactions	DRP1, DNM1L, OPA1, AKT, TBK1, MCU
KG Connections	507 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VDAC1 — AlphaFold P21796 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VDAC1["VDAC1"]
    VDAC1 -->|"activates"| Cancer["Cancer"]
    VDAC1 -->|"activates"| Als["Als"]
    VDAC1 -->|"activates"| Inflammation["Inflammation"]
    VDAC1 -->|"activates"| Alzheimer["Alzheimer"]
    VDAC1 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    VDAC1 -->|"target for"| Parkinson["Parkinson"]
    VDAC1 -->|"activates"| Ms["Ms"]
    VDAC1 -->|"activates"| Depression["Depression"]
    VDAC1 -->|"activates"| Hepatitis["Hepatitis"]
    VDAC1 -->|"activates"| Senescence["Senescence"]
    SQSTM1["SQSTM1"] -->|"binds"| VDAC1
    GPCPD1["GPCPD1"] -->|"binds"| VDAC1
    DNM1L["DNM1L"] -->|"activates"| VDAC1
    KRAS["KRAS"] -->|"expressed in"| VDAC1
    DRP1["DRP1"] -->|"activates"| VDAC1
    CXCL10["CXCL10"] -->|"activates"| VDAC1
    DSDNA["DSDNA"] -->|"activates"| VDAC1
    STING["STING"] -->|"activates"| VDAC1
    MTDNA["MTDNA"] -->|"activates"| VDAC1
    CGAS["CGAS"] -->|"activates"| VDAC1

Outgoing (330)

Target	Relation	Type	Str
mtDNA efflux	mediates	process	0.95
MAMs	involved_in	process	0.95
Cancer	activates	disease	0.95
GRP75	interacts_with	protein	0.90
Hepatic Ischemia-Reperfusion Injury	biomarker_for	disease	0.90
CANCER	activates	gene	0.90
Metabolic Flexibility	associated_with	phenotype	0.85
Mitochondrial Calcium Uptake	involved_in	process	0.85
mitochondrial calcium uptake	modulates	process	0.85
Mitochondrial Respiration	involved_in	pathway	0.80
mitochondrial membrane permeability	regulates	biological_process	0.80
calcium balance	regulates	biological_process	0.80
programmed cell death pathways	facilitates	biological_process	0.80
amyloid-β	interacts_with	protein	0.80
α-synuclein	interacts_with	protein	0.80
mutant SOD1	interacts_with	protein	0.80
Alzheimer's disease	associated_with	disease	0.80
Mitophagy	involved_in	process	0.80
amyotrophic lateral sclerosis	implicated_in	disease	0.80
ALZHEIMER	associated_with	disease	0.80
APOPTOSIS	activates	gene	0.80
Apoptosis	activates	pathway	0.80
Cardiac	activates	disease	0.75
Tumor	activates	disease	0.75
Colorectal Cancer	biomarker_for	disease	0.75
PARKIN	regulates	gene	0.70
MCU	activates	gene	0.70
Disulfidptosis	involved_in	process	0.70
Mtor	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
Autophagy	activates	pathway	0.70
MITOPHAGY	activates	gene	0.70
Er Stress	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
MITOCHONDRIA	regulates	gene	0.70
MITOPHAGY	regulates	gene	0.70
Mitophagy	regulates	pathway	0.70
Als	activates	disease	0.65
Tumor	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Depression	activates	disease	0.65
Hepatitis	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Senescence	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Stroke	activates	disease	0.65

Incoming (177)

Source	Relation	Type	Str
GAΒ	interacts_with	protein	0.95
SQSTM1	binds	gene	0.80
GPCPD1	binds	gene	0.80
DNM1L	activates	gene	0.60
DRP1	activates	gene	0.60
CXCL10	activates	gene	0.60
STING	activates	gene	0.60
CGAS	activates	gene	0.60
IRF3	activates	gene	0.60
CCL5	activates	gene	0.60
RAGE	therapeutic_target	gene	0.60
APP	inhibits	gene	0.60
AKT	activates	gene	0.60
OPA1	activates	gene	0.60
DRP1	regulates	gene	0.60
BNIP3	inhibits	gene	0.60
YWHAZ	associated_with	gene	0.60
BAX	activates	gene	0.60
BAX	associated_with	gene	0.60
PRKN	regulates	gene	0.60
PARKIN	interacts_with	gene	0.60
NLRP3	regulates	gene	0.60
GPX4	activates	gene	0.60
PI3K	activates	gene	0.60
NRF2	activates	gene	0.60
SNCA	expressed_in	gene	0.60
NDUFS1	therapeutic_target	gene	0.60
CYCS	expressed_in	gene	0.60
HSPA9	expressed_in	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
SDHA	expressed_in	gene	0.60
ACO2	expressed_in	gene	0.60
NDUFS2	therapeutic_target	gene	0.60
GLUD1	therapeutic_target	gene	0.60
P2X7	activates	gene	0.60
NLRP3	activates	gene	0.60
UBC	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
PINK1	regulates	gene	0.60
CSNK2A2	regulates	gene	0.60
LRPPRC	activates	gene	0.60
GLUD1	activates	gene	0.60
NDUFS1	activates	gene	0.60
NDUFS2	activates	gene	0.60
CX3CR1	activates	gene	0.60
FUNDC1	regulates	gene	0.60
CGAS	associated_with	gene	0.60
SORL1	inhibits	gene	0.60
PRKCI	therapeutic_target	gene	0.60
ACO2	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VDAC1

Understanding Entity Pages

Summary

Wiki Pages (21)

VDAC1 — Voltage Dependent Anion Channel 1

Mitophagy Pathway in Neurodegeneration

JPH2 — Junctophilin 2

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

endoplasmic-reticulum-stress

Ubiquitin-Proteasome System Dysfunction in Parkinson's Disease

Section 103: Sirtuin Pathway and NAD+-Dependent Deacetylases in CBS/PSP

ER Stress in Corticobasal Syndrome

GSK-3β

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

PINK1-Parkin Mitophagy Pathway in Parkinson's Disease

Mitochondria-Lysosome Contact Sites (MLCS) in Neurodegeneration

FBXO7 Protein (PARK15)

Mitophagy

timm17a

Sirtuin Modulators for Parkinson's Disease

PARK2 - Parkin

sglt2-inhibitors-neurodegeneration

Parkin Activators for Parkinson's Disease