gene

VDAC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VDAC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

503Connections

4Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

Page for VDAC1 — Voltage Dependent Anion Channel 1

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	VDAC1
Full Name	Voltage Dependent Anion Channel 1
Chromosome	5q31
Protein Type	Channel
Function	VDAC1 encodes the voltage-dependent anion channel 1, also known as porin.
Primary Expression	Brain, Heart, Liver, Kidney
Molecular Weight	31 kDa
Pathways	Apoptosis, Autophagy, Er Stress, Glycolysis, Mitochondrial Function
UniProt ID	P21796
NCBI Gene ID	7416
Ensembl ID	ENSG00000110833
GeneCards	VDAC1
Human Protein Atlas	VDAC1
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis
Interactions	aco2, ACO2, AKT, ALS, ALZHEIMER'S DISEASE, AMPK
SciDEX Hypotheses	Mitochondrial Contact Site Stabilization Synaptic VDAC1-Mediated Mitochondrial Tau Traffick
KG Connections	503 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VDAC1 — AlphaFold P21796 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VDAC1 — Voltage Dependent Anion Channel 1

gene · 1007 words

→

VDAC1 Protein

protein · 589 words

→

Pathway Diagram

graph TD
    VDAC1["VDAC1"]
    VDAC1 -->|"activates"| Cancer["Cancer"]
    VDAC1 -->|"activates"| Als["Als"]
    VDAC1 -->|"activates"| Inflammation["Inflammation"]
    VDAC1 -->|"activates"| Alzheimer["Alzheimer"]
    VDAC1 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    VDAC1 -->|"target for"| Parkinson["Parkinson"]
    VDAC1 -->|"activates"| Ms["Ms"]
    VDAC1 -->|"activates"| Depression["Depression"]
    VDAC1 -->|"activates"| Hepatitis["Hepatitis"]
    VDAC1 -->|"activates"| Senescence["Senescence"]
    SQSTM1["SQSTM1"] -->|"binds"| VDAC1
    GPCPD1["GPCPD1"] -->|"binds"| VDAC1
    DNM1L["DNM1L"] -->|"activates"| VDAC1
    KRAS["KRAS"] -->|"expressed in"| VDAC1
    DRP1["DRP1"] -->|"activates"| VDAC1
    CXCL10["CXCL10"] -->|"activates"| VDAC1
    DSDNA["DSDNA"] -->|"activates"| VDAC1
    STING["STING"] -->|"activates"| VDAC1
    MTDNA["MTDNA"] -->|"activates"| VDAC1
    CGAS["CGAS"] -->|"activates"| VDAC1

Outgoing (331)

Target	Relation	Type	Str
mtDNA efflux	mediates	process	0.95
MAMs	involved_in	process	0.95
Cancer	activates	disease	0.95
Hepatic Ischemia-Reperfusion Injury	biomarker_for	disease	0.90
GRP75	interacts_with	protein	0.90
CANCER	activates	gene	0.90
Metabolic Flexibility	associated_with	phenotype	0.85
mitochondrial calcium uptake	modulates	process	0.85
Mitochondrial Calcium Uptake	involved_in	process	0.85
mitochondrial membrane permeability	regulates	process	0.80
Alzheimer's disease	associated_with	disease	0.80
amyotrophic lateral sclerosis	implicated_in	disease	0.80
mutant SOD1	interacts_with	protein	0.80
Mitophagy	associated_with	process	0.80
amyloid-β	interacts_with	protein	0.80
calcium balance	regulates	process	0.80
Mitochondrial Respiration	involved_in	pathway	0.80
α-synuclein	interacts_with	protein	0.80
programmed cell death pathways	facilitates	process	0.80
Apoptosis	activates	pathway	0.80
APOPTOSIS	activates	gene	0.80
ALZHEIMER	associated_with	disease	0.80
Cardiac	activates	disease	0.75
Colorectal Cancer	biomarker_for	disease	0.75
Tumor	activates	disease	0.75
MCU	activates	gene	0.70
tau protein	regulates	protein	0.70
MAPT	regulates	gene	0.70
mitochondrial-ER contacts	regulates	structure	0.70
PARKIN	regulates	gene	0.70
Calcium Homeostasis	regulates	phenotype	0.70
MITOCHONDRIA	regulates	gene	0.70
MITOPHAGY	activates	gene	0.70
MITOPHAGY	regulates	gene	0.70
Er Stress	activates	pathway	0.70
Autophagy	activates	pathway	0.70
Mitophagy	regulates	pathway	0.70
Mtor	activates	pathway	0.70
Disulfidptosis	involved_in	process	0.70
Mitophagy	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Heart Failure	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	activates	disease	0.65
Senescence	activates	disease	0.65

Incoming (172)

Source	Relation	Type	Str
GAΒ	interacts_with	protein	0.95
GPCPD1	binds	gene	0.80
SQSTM1	associated_with	gene	0.80
CXCL10	activates	gene	0.60
IRF3	activates	gene	0.60
CCL5	activates	gene	0.60
HSPA9	targets	gene	0.60
APP	inhibits	gene	0.60
AKT	activates	gene	0.60
ACO2	targets	gene	0.60
DRP1	regulates	gene	0.60
BNIP3	inhibits	gene	0.60
YWHAZ	associated_with	gene	0.60
BAX	activates	gene	0.60
DRP1	activates	gene	0.60
RAGE	therapeutic_target	gene	0.60
PARKIN	interacts_with	gene	0.60
NLRP3	regulates	gene	0.60
GPX4	activates	gene	0.60
PI3K	activates	gene	0.60
OPA1	activates	gene	0.60
CGAS	activates	gene	0.60
NDUFS1	therapeutic_target	gene	0.60
CYCS	expressed_in	gene	0.60
HSPA9	expressed_in	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
SDHA	expressed_in	gene	0.60
ACO2	expressed_in	gene	0.60
NDUFS2	therapeutic_target	gene	0.60
GLUD1	therapeutic_target	gene	0.60
BAX	associated_with	gene	0.60
STING	activates	gene	0.60
PRKN	regulates	gene	0.60
P2X7	activates	gene	0.60
NLRP3	activates	gene	0.60
UBC	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
PINK1	regulates	gene	0.60
CSNK2A2	regulates	gene	0.60
LRPPRC	activates	gene	0.60
GLUD1	activates	gene	0.60
NDUFS1	activates	gene	0.60
NDUFS2	activates	gene	0.60
NRF2	activates	gene	0.60
SNCA	expressed_in	gene	0.60
CX3CR1	activates	gene	0.60
FUNDC1	regulates	gene	0.60
CGAS	associated_with	gene	0.60
SORL1	inhibits	gene	0.60
DNM1L	activates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
MCU Calcium Overload via MFN2/GRP75/VDAC1 MAM Dysfunction	0.644	neurodegeneration	What upstream mechanisms cause TDP-43 to
VDAC1 Hyper-Oligomerization via Direct TDP-43 Binding	0.496	neurodegeneration	What upstream mechanisms cause TDP-43 to
Mitochondrial Contact Site Stabilization	0.455	neurodegeneration	Which specific metabolic pathways in APO
Synaptic VDAC1-Mediated Mitochondrial Tau Trafficking	0.000	-	Tau propagation mechanisms and therapeut