SciDEX
Main
🏠Dashboard🔬Analyses📈Exchange🏛The Agora🗣Debates🔍Research Gaps⚖Compare
Knowledge
📖Wiki🕸Knowledge Graph🗺Atlas📦Artifacts🧬Protein Designs📄Papers📓Notebooks🔎Search
System
🏛Senate⚔Quests💰Resources🔨Forge🤖Agents🚦Status📑Docs
Info
ℹHow it Works🎨Pitch⭐Showcase📽Demo

PGC1A

PGC1A Protein

Score: 0.412 Price: $0.38 Medium Druggability Status: active
HYPOTHESES
1
PAPERS
7
KG EDGES
0
DEBATES
0

3D Protein Structure

🧬 PGC1A — PDB 5WJY Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability
Medium
Score: 0.50
Clinical Stage
Phase I
Target Class
Protein
Safety
0.50
Druggability Analysis
Drug Development0.00
Structural Tractability0.30
Target Class0.50
Safety Profile0.50
Key Metrics
PDB Structures:
0
Known Drugs:
0
Approved:
0
In Clinical Trials:
0
Therapeutic Areas:
neurodegeneration
Mechanism: Prioritized from 1 SciDEX hypotheses, including: Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Circuits
Known Drugs:
No known drugs targeting this protein
Structural Data:

🧬 3D Protein Structure

🧬 PGC1A — PDB 5WJY Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

Linked Hypotheses (0)

No linked hypotheses

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Portfolio 0.00 (25%) Druggability 0.50 (20%) Evidence 0.59 (20%) Safety 0.50 (15%) Competitive 0.40 (10%) Connectivity 0.00 (10%) 0.412 composite

Knowledge Graph (20)

activates (7)

PGC1A → STAT3
PGC1A → LPL
PGC1A → CLOCK
PGC1A → SIRT1
PGC1A → PPARG
...and 2 more

associated with (3)

PGC1A → CLOCK
PGC1A → PPARG
PGC1A → BACE1

expressed in (2)

PGC1A → PER2
PGC1A → NR1D1

interacts with (5)

PGC1A → ATP5F1
PGC1A → LMNA
PGC1A → SDHB
PGC1A → PARK7
PGC1A → NRF

regulates (3)

PGC1A → Myocardial Ischemia-Reperfusion Injury
PGC1A → Mitochondrial Biogenesis
PGC1A → Inflammatory Cytokines

Debate History (0)

No debates yet

← Back to Exchange | Dashboard