gene 614 words KG: NRF1 2026-03-24
kind:genesection:genesstate:published
Contents

NRF1 Gene

🧬 Gene Info
Gene SymbolNRF1
Full NameNRF1
Chromosome5q31.1
Protein TypeGene
FunctionNRF1 is a critical transcription factor that coordinates the expression of genes involved in mitochondrial function and cellular respiration: [@srensen2020]
Primary Expressiontissues with high energy demands:
PathwaysApoptosis, Autophagy, Chaperone, Cholesterol, Differentiation
NCBI Gene IDSearch NCBI
GeneCardsNRF1
Human Protein AtlasNRF1
Associated DiseasesALS, Aging, Alzheimer, Breast Cancer, Cancer
Known Drugs/Compoundsnicotinamide, rapamycin
InteractionsDRP1, OPA1, MFN1, NRF2, PKC, MAF
KG Connections490 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (22)

Ancestry-Adapted Mitochondrial Rescue Therapy
Score: 0.45
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (13)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (2)

Sirtuin Pathway Dysfunction Validation in Parkinson's Diseas
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 9 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 9 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 9 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 9 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 9 hypotheses

Knowledge Graph (12 edges)

NRF1 activates TFAM
NRF1 therapeutic_target PPARGC1A
NRF1 therapeutic_target SIRT1
NRF1 therapeutic_target DNM1L
NRF1 activates DRP1
NRF1 therapeutic_target PRKAA1
NRF1 therapeutic_target JUN
NRF1 activates OPA1
NRF1 activates MFN1
NRF1 activates NRF2