gene 1,621 words KG: PPARG
Contents

PPARG — Peroxisome Proliferator-Activated Receptor Gamma

🧬 Gene Info
Gene SymbolPPARG
Full NamePeroxisome Proliferator-Activated Receptor Gamma
Chromosome3p25.2.
Protein TypeReceptor
Functionis a member of the nuclear receptor superfamily of ligand-activated transcription factors.
Primary Expressionneurons, astrocytes, and microglia, where it modulates neuroinflammation, mitochondrial function, synaptic plasticity, and cellular survival
Molecular Weight56 kDa
Amino Acids505 aa
Exons9
PathwaysAkt, Apoptosis, Autophagy, Cholesterol, Glycolysis
Ensembl IDENSG00000132170
GeneCardsPPARG
Human Protein AtlasPPARG
Alternative promotersDistinct TSS for PPARG1 and PPARG2
Epigenetic controlCpG island in promoter region
Associated DiseasesAD, ADH, ALS, AMI, Alzheimer
Known Drugs/CompoundsGW9662, ibuprofen, Betulinic Acid, rapamycin, Abscisic acid, endogenous ligands
InteractionsHSPA5, MAVS, FIP200, AMBRA1, APC, RHEB
KG Connections1206 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48
HDAC3-Selective Inhibition for Clock Reset
Score: 0.46
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67

Related Analyses (14)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (1)

Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates
AMBRA1 Gene
gene · KG edge: interacts_with
ALDH2 — Aldehyde Dehydrogenase 2
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

PPARG interacts_with PGC1A
PPARG activates RAB7A
PPARG activates RPS6
PPARG activates RPS6KB1
PPARG activates RUBCN
PPARG activates SQSTM1
PPARG activates SREBF1
PPARG phosphorylates RB1CC1
PPARG phosphorylates RHEB
PPARG phosphorylates RICTOR