gene 1,282 words KG: FASN 2026-03-24
kind:genesection:genesstate:published
Contents

FASN Gene

🧬 Gene Info
Gene SymbolFASN
Chromosome1q25
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight273 kDa
PathwaysAkt, Lipid Metabolism, Mtor, Pi3K
Ensembl IDENSG00000169710
GeneCardsFASN
Human Protein AtlasFASN
Associated DiseasesAD, AMI, ARM, Aging, Atherosclerosis, Cancer
InteractionsSRC, HK1, MTOR, PTEN, HK2, BAX
KG Connections365 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (24)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: expressed_in
BAX Gene
gene · KG edge: inhibits
ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator
gene · KG edge: regulates

Knowledge Graph (12 edges)

FASN activates SRC
FASN activates HK1
FASN activates MTOR
FASN activates PTEN
FASN activates HK2
FASN inhibits BAX
FASN inhibits ALOX15
FASN inhibits GSDMD
FASN inhibits SCD1
FASN inhibits HMGCR