| Gene Symbol | HDAC3 |
| Full Name | Histone Deacetylase 3 |
| Chromosome | 5q31.3. |
| Protein Type | Epigenetic Regulator |
| Target Class | Epigenetic Regulator |
| Function | HDAC3 encodes histone deacetylase 3, a class I histone deacetylase that catalyzes the removal of acetyl groups from lysine residues on histone proteins. |
| Mechanism of Action | Small molecule inhibitor of histone deacetylase enzymatic activity |
| Primary Expression | Ubiquitous with highest expression in brain |
| Druggability | Low (0.41) |
| Clinical Stage | Approved |
| Molecular Weight | 33 kDa |
| Amino Acids | 428 aa |
| Pathways | Autophagy, Epigenetic, Memory, Neuroprotection, Oxidative Stress |
| UniProt ID | O15379 |
| Ensembl ID | ENSG00000171720 |
| OMIM | 605166 |
| GeneCards | HDAC3 |
| Human Protein Atlas | HDAC3 |
| Associated Diseases | AGING, ALS, Alzheimer, Alzheimer'S Disease, Cancer |
| Known Drugs/Compounds | Kaempferol, H3K9, NICOTINAMIDE, RGFP966, nicotinamide, valproic acid |
| Interactions | TRKB, BDNF, BMAL1, NRF1, NRF2, TNF |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Selective HDAC3 Inhibition with Cognitive Enhancem HDAC3-Selective Inhibition for Clock Reset |
| KG Connections | 1113 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |