| Gene Symbol | PIEZO1 |
| Full Name | Piezo Type Mechanosensitive Ion Channel Component 1 |
| Chromosome | 16q24.3 |
| Protein Type | Ion Channel |
| Target Class | Ion Channel |
| Function | Small molecule modulator of mechanosensitive ion channel activity |
| Mechanism of Action | Small molecule modulator of mechanosensitive ion channel activity |
| Primary Expression | microglia, astrocytes, and brain endothelial cells, where it transduces mechanical cues from the ti |
| Druggability | Low (0.42) |
| Clinical Stage | Phase I |
| Molecular Weight | 286 kDa |
| Amino Acids | 521 aa |
| Exons | 51 |
| Pathways | Angiogenesis, Apoptosis, Autophagy, Calcium Signaling, Epigenetic |
| UniProt ID | Q9H5I5 |
| NCBI Gene ID | 9780 |
| Ensembl ID | ENSG00000103335 |
| OMIM | 611184 |
| GeneCards | PIEZO1 |
| Human Protein Atlas | PIEZO1 |
| Associated Diseases | Als, Alzheimer, Atherosclerosis, Bacterial Infection, calcium influx |
| Known Drugs/Compounds | artemisinin, Paeoniflorin, Yoda1 |
| Interactions | Actin, ADAMTS5, AGING, AKT, ALS, ALZHEIMER'S DISEASE |
| SciDEX Target | View Target Profile (5 clinical trials) |
| SciDEX Hypotheses | Extracellular Matrix Stiffness Modulation Piezo1 Channel Inhibition Prevents Mechanical Ampl |
| KG Connections | 925 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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