concept

PAEONIFLORIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PAEONIFLORIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

37Outgoing

2Incoming

0Experiments

0Debates

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Pathway Diagram

graph TD
    PAEONIFLORIN["PAEONIFLORIN"]
    PAEONIFLORIN -.protects against.-> Drug_Induced_Liver_Injury["Drug-Induced Liver Injury"]
    PAEONIFLORIN -.protects against.-> APAP_induced_Hepatic_Damage["APAP-induced Hepatic Damage"]
    PAEONIFLORIN -->|"treats"| Acetaminophen_Induced_Hepatic_["Acetaminophen-Induced Hepatic Damage"]
    PAEONIFLORIN -->|"activates"| Autophagy["Autophagy"]
    PAEONIFLORIN -->|"modulates"| MAPK_Signaling["MAPK Signaling"]
    PAEONIFLORIN -->|"inhibits"| MAPK["MAPK"]
    PAEONIFLORIN -->|"inhibits"| mTOR["mTOR"]
    PAEONIFLORIN -->|"contributes to"| LC3["LC3"]

Outgoing (37)

Target	Relation	Type	Str
HSF1	upregulates	gene	0.95
NRF1	upregulates	gene	0.95
APAP-induced Hepatic Damage	protects_against	disease	0.95
Drug-Induced Liver Injury	protects_against	disease	0.95
PIEZO1	binds	gene	0.95
PIEZO1	therapeutic_target	gene	0.93
Acetaminophen-Induced Hepatic Damage	treats	disease	0.93
Endothelial-Mesenchymal Transition	suppresses	process	0.92
Renal Fibrosis	treats	disease	0.92
Autophagy	activates	process	0.92
MAPK Signaling	modulates	pathway	0.91
mTOR Signaling	downregulates	pathway	0.90
Th17/Treg balance	regulates	process	0.90
Apoptosis	inhibits	process	0.90
TNF	downregulates	gene	0.90
BDNF	upregulates	gene	0.90
MAPK	inhibits	protein	0.90
mTOR	inhibits	protein	0.90
ATG7	contributes_to	protein	0.90
ATG5	contributes_to	protein	0.90
LC3	contributes_to	protein	0.90
Microvascular Rarefaction	protects_against	phenotype	0.90
BECN1	contributes_to	protein	0.90
CDH5	upregulates	gene	0.88
NOS3	upregulates	gene	0.88
MTOR	downregulates	gene	0.88
P38	targets	protein	0.88
Hepatocyte Apoptosis	inhibits	process	0.88
ATG5	upregulates	gene	0.87
Extracellular Matrix Deposition	suppresses	process	0.87
Rorγt	binds	protein	0.85
FOXP3	binds	gene	0.85
Reactive Oxygen Species	modulates	process	0.85
p38	targets	protein	0.85
LC3	upregulates	protein	0.85
Parkinson'S Disease	protects_against	disease	0.85
MITOCHONDRIA	modulates	cell_type	0.80

Incoming (2)

Source	Relation	Type	Str
RORC	interacts_with	gene	0.85
FOXP3	interacts_with	gene	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity