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RAB7A — RAB7A, Member RAS Oncogene Family

🧬 Gene Info

Gene Symbol	RAB7A
Full Name	RAB7A, Member RAS Oncogene Family
Chromosome	3q21
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	RAB7A encodes a small GTPase that regulates late endosomal trafficking and lysosomal function.
Mechanism of Action	RAB7A inhibitors or modulators would block or enhance GTPase-mediated late endosome and lysosome trafficking, disrupting autophagy flux and lysosomal degradation pathways. This can either impair pathogenic protein clearance (in certain cancers) or restore lysosomal function (in storage disorders and neurodegeneration).
Druggability	High (0.75)
Clinical Stage	Phase III
Pathways	Autophagy, LIPOPHAGY, Mitophagy, Mtor, Oxidative Stress
UniProt ID	A0A6Q8PGE6
Ensembl ID	ENSG00000175756
OMIM	602298
GeneCards	RAB7A
Human Protein Atlas	RAB7A
Associated Diseases	AD, ADH, ALS, AMI, Alzheimer
Known Drugs/Compounds	rapamycin, Lactate, Llome
Interactions	RILP, TBK1, ATG4B, ATG3, CAT, G3BP1
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	Mitochondrial-Lysosomal Contact Site Engineering
KG Connections	885 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Knowledge Graph