| Gene Symbol | AMPK |
| Aliases | AMPKPROTEIN |
| Subcellular Localization | </strong></td><td>Cytoplasm, Nucleus (shuttles)</td></tr> |
| Pathways | AGING, Autophagy, Mitochondrial Biogenesis, Mitophagy |
| GeneCards | AMPK |
| Human Protein Atlas | AMPK |
| LKB1 (STK11) | The major AMPK kinase, constitutively active, responds to metabolic stress |
| CaMKKβ (CAMKK2) | Calcium/calmodulin-dependent kinase that activates AMPK in response to Ca²⁺ signals |
| TAK1 | Can phosphorylate AMPK in response to cytokine signaling |
| ATP/AMP ratio monitoring | Detects even small changes in cellular energy status |
| Metabolic stress response | Activates when ATP falls below threshold |
| Cellular adaptation | Coordinates rapid and long-term metabolic responses |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | 17β-estradiol, acteoside, Aloe-emodin, Alpha-Ketoglutarate, BAICALEIN, BERBERINE |
| Interactions | 4E-BP1, 6-OHDA, ABCA1, ABCA7, ABCD3, ABCG1 |
| KG Connections | 4737 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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