gene

NCT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

24Hypotheses

30Analyses

11Outgoing

4Incoming

Summary

NCT (Nicastrin) Gene

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🧬 Gene Info

Gene Symbol	AB
Full Name	1005 GDNF Gene Therapy Long-Term Follow-up Study
Aliases	NCT
Chromosome	1p31.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Pathways	circadian regulation
UniProt ID	Q92542
NCBI Gene ID	51594
Ensembl ID	ENSG00000103546
GeneCards	AB
Human Protein Atlas	AB
Phase	Long-term Follow-up (Observational)
Status	Enrolling by invitation
Study Type	Observational
Associated Diseases	Alzheimer
Interactions	PSEN, VCP, PS1, TAU, APH1, APP
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NCT — AlphaFold Q92542 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NCT["NCT"]
    style NCT fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    circadian_regulation(["circadian regulation"])
    neurodegeneration["neurodegeneration"]

    NCT -->|"participates_in"| circadian_regulation
    NCT -->|"implicated_in"| neurodegeneration

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class circadian_regulation protein
    class neurodegeneration disease

Outgoing (11)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
PSEN	activates	gene	0.60
neurodegeneration	interacts_with	disease	0.60
VCP	interacts_with	gene	0.60
VCP	activates	gene	0.60
PS1	associated_with	gene	0.60
PS1	activates	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
circadian regulation	participates_in	pathway	0.55

Incoming (4)

Source	Relation	Type	Str
TAU	interacts_with	gene	0.60
APH1	activates	gene	0.60
APP	regulates	gene	0.60
APP	activates	gene	0.60

Targeting Hypotheses (24)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop optogenetic targeting PV interneurons to restore	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbate	0.610	-	Do β-amyloid plaques and neurofibrillary
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.569	neurodegeneration	What is the molecular mechanism by which
ER Stress Reduction as Adjunctive Therapy to Support Autopha	0.566	neurodegeneration	Why does iron chelation therapy worsen o
SYK-Independent TREM2 Pathways Remain Functional in TYROBP D	0.555	neuroinflammation	Why is TYROBP deficiency neuroprotective

Glymphatic-Mediated Tau Clearance Dysfunction	0.546	neuroscience	Circuit-level neural dynamics in neurode
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated
C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by	0.537	neurodegeneration	How does PIKFYVE inhibition activate unc
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Sign	0.533	neuroscience	Circuit-level neural dynamics in neurode
TREM2-Mediated Microglial Dysfunction Disrupts Perivascular	0.527	neuroscience	Circuit-level neural dynamics in neurode
BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb	0.527	neurodegeneration	What are the physiological functions of
TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina	0.520	neurodegeneration	How do the seven novel ALS genes functio
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK	0.509	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.499	neuroinflammation	Why do TAM receptors protect against neu
Astroglial Gap Junction Coordination via Connexin-43 Phospho	0.497	neurodegeneration	Perivascular spaces and glymphatic clear
CRISPR-Mediated Mitochondrial Genome Editing for Complex I D	0.491	neurodegeneration	CRISPR-based therapeutic approaches for
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Rece	0.489	neuroscience	Circuit-level neural dynamics in neurode
C1q Inhibition Prevents Synaptic Mitochondrial Dysfunction v	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica
TREM2-Mediated Microglial Dysfunction Disrupts Oligodendrocy	0.452	neuroscience	Circuit-level neural dynamics in neurode
Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Sign	0.434	neuroscience	Circuit-level neural dynamics in neurode
Correcting Gut Microbial Dopamine Imbalance to Support Syste	0.412	neurodegeneration	What are the mechanisms by which gut mic
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction	0.398	neurodegeneration	Metabolic reprogramming in neurodegenera
Brain Insulin Resistance with Glucose Transporter Dysfunctio	0.398	neurodegeneration	Metabolic reprogramming in neurodegenera
Gap Junction Hemichannel Modulation for Controlled Mitochond	0.386	neurodegeneration	Mitochondrial transfer between neurons a

Mentioning Analyses (30)

Scientific analyses that reference this entity

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.596

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.497

What are the physiological functions of BACE1 beyond APP processing that could c

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576

Why does autophagy inhibition improve neuronal survival when autophagy is typica

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Plasma pTau 217/β-amyloid 1-42 ratio for enhanced accuracy and reduced uncertain [PMID:41562409]	Benina N, Buitrago L, De Simone FI, Radw	Brain	2026
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026
Nicotinic acetylcholine receptor activation induces BACE1 transcription via the [PMID:38110001]	Nakano M, Tsuchida T, Mitsuishi Y, Nishi	Neurosci Res	2024
The influence of inhibiting or stimulating the expression of the α3 subunit of t [PMID:23201341]	Qi XL, Zhang XL, Ou-Yang K, Shan KR, Gua	Neurochem Int	2013
[Influence of inhibited α7 nicotinic acetylcholine receptor gene expression on t [PMID:23324234]	Ouyang K, Qi XL, Guan ZZ	Zhonghua Bing Li Xue Za Zhi	2012
Effects of galantamine on β-amyloid release and beta-site cleaving enzyme 1 expr [PMID:20600777]	Li Q, Wu D, Zhang L, Zhang Y	Exp Gerontol	2010
Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued b [PMID:20943921]	Wang H, Song L, Lee A, Laird F, Wong PC	J Neurosci	2010
Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy. [PMID:20301376]	Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa		1993

NCT

Understanding Entity Pages

Summary

Wiki Pages (21)

AB-1005 GDNF Gene Therapy Long-Term Follow-up Study

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Sleep and Circadian Dysfunction in Alzheimer's Disease

Atypical Parkinsonism

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

PI-2620 Tau PET in PSP

nct07165106

coq10-neurodegeneration

CBS/PSP Clinical Trials Guide

Neurotrophin Signaling Pathways in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Lithium for PSP/CBS — Phase 2 Trial

dimethyl-fumarate-nrf2-ad-nct06850597

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

A Phase 3, Randomised, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy, Tolerability, and Safety of Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's Disease

PMN310 Anti-Amyloid for AD (NCT06750432)

FEEMSA Study: Laryngopharyngeal Function in Neurodegenerative Diseases (NCT04706234)

metal-ion-synuclein-mitochondria-axis-parkinsons

Pathway Diagram

Outgoing (11)

Incoming (4)

Targeting Hypotheses (24)

Mentioning Analyses (30)

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

Are interneuron oscillation deficits compensatory responses or primary pathologi

What are the physiological functions of BACE1 beyond APP processing that could c

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

Why does autophagy inhibition improve neuronal survival when autophagy is typica

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

What are the specific circulating factors in exercise-conditioned plasma that me

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

What molecular mechanisms enable functional recovery and muscle re-innervation a

What signals trigger microglia to specifically recognize and phagocytose LC axon

How do P/Q channel deficits paradoxically increase thalamic excitability despite

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

Why do TAM receptors protect against neuroinvasive viruses despite their known i

Why do TAM receptors protect against neuroinvasive viruses despite their known i

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

Which tau PTMs are both disease-specific and druggable with selective small mole

How can functional hyperconnectivity patterns distinguish compensatory mechanism

What is the relative contribution of connexin-43 gap junctions vs tunneling nano

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

How does APOE4's beneficial immune function reconcile with its established role

What is the high-resolution structure of the APOE4 hinge region and its role in

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do transferred mitochondria from diseased astrocytes carry pathological damage t

Do chronic stress granule inhibition strategies impair normal cellular stress re

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Do circadian disruptions cause neurodegeneration or result from it?

Related Papers (8)