gene 787 words KG: APLP1 2026-03-27
kind:genesection:genestopic:alzheimersstate:published
Contents

APLP1 Gene

🧬 Gene Info
Gene SymbolAPLP1
Full NameAmyloid Beta Precursor-Like Protein 1
Chromosome19q13.3
Functionis a type I transmembrane glycoprotein expressed predominantly in the nervous system, where it participates in diverse cellular processes including synapse development, plasticity, and network exci...
Primary Expressionthe central nervous system with particularly high levels in the hippocampus (especially CA1 pyramidal neurons and dentate gyrus granule cells), cerebr
Amino Acids770 aa
UniProt ID[Q15804](https://www.uniprot.org/uniprot/Q15804)
Ensembl IDENSG00000105248
GeneCardsAPLP1
Human Protein AtlasAPLP1
Associated DiseasesAls
Known Drugs/Compoundscurcumin, resveratrol
InteractionsAKT, ADAM10, SOD1, APOE, CLDN5, MMP9
KG Connections101 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

APLP1 activates AKT
APLP1 protects_against APP
APLP1 activates ADAM10
APLP1 regulates NPAS4
APLP1 regulates APP
APLP1 involved_in Alpha-Synuclein Transmission
APLP1 interacts_with SOD1
APLP1 interacts_with APOE
APLP1 interacts_with CLDN5
APLP1 interacts_with MMP9