Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about aplp2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | APLP2 |
| Full Name | Amyloid Beta Precursor-Like Protein 2 |
| Aliases | Amyloid Precursor-Like Protein 2 |
| Chromosome | 15q24.2 |
| Function | encodes a protein of approximately 763 amino acids. |
| Primary Expression | neurons, astrocytes, oligodendrocytes, and microglia, with regional distribution in cerebral cortex, hippocampus, cerebellum, thalamus, and hypothalam |
| Molecular Weight | 87 kDa |
| Amino Acids | 763 aa |
| UniProt ID | [Q06481](https://www.uniprot.org/uniprot/Q06481) |
| Ensembl ID | ENSG00000145087 |
| GeneCards | APLP2 |
| Human Protein Atlas | APLP2 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
APLP2["APLP2"]
APLP2 -.protects against.-> Als["Als"]
APLP2 -->|"activates"| Aging["Aging"]
APLP2 -->|"regulates"| Alzheimer["Alzheimer"]
APLP2 -->|"regulates"| Ms["Ms"]
APLP2 -->|"contributes to"| Cancer["Cancer"]
AGING["AGING"] -->|"activates"| APLP2| Target | Relation | Type | Str |
|---|---|---|---|
| Synaptic Plasticity | regulates | process | 0.90 |
| APP | associated_with | gene | 0.70 |
| Als | protects_against | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Cancer | contributes_to | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Alzheimer | contributes_to | disease | 0.65 |
| APLP1 | protects_against | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| APP | protects_against | gene | 0.60 |
| ADAM10 | activates | gene | 0.60 |
| APLP1 | regulates | gene | 0.60 |
| NPAS4 | regulates | gene | 0.60 |
| APP | regulates | gene | 0.60 |
| APLP1 | associated_with | gene | 0.60 |
| APP | targets | gene | 0.60 |
| APP | activates | gene | 0.60 |
| Akt | activates | pathway | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| Notch | regulates | pathway | 0.60 |
| ALZHEIMER'S DISEASE | interacts_with | gene | 0.60 |
| APOPTOSIS | interacts_with | gene | 0.60 |
| Apoptosis | interacts_with | pathway | 0.60 |
| ALZHEIMER | contributes_to | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| CANCER | contributes_to | gene | 0.60 |
| ALZHEIMER'S DISEASE | contributes_to | gene | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| benchmark_ot_ad_answer_key:APLP2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APP | interacts_with | protein | 0.85 |
| APLP1 | targets | gene | 0.60 |
| APLP1 | activates | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:APLP2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||