| Gene Symbol | C3 |
| Chromosome | 19p13.3 |
| Target Class | Signaling Protein |
| Mechanism of Action | Small molecule inhibitor of complement activation or convertase activity |
| Druggability | Medium (0.50) |
| Clinical Stage | Approved |
| Category | Neuroinflammation Biomarker |
| Target | C3 protein, C3a, C3b, C3c, C3d fragments |
| Sample Type | CSF, Plasma, Serum |
| Sensitivity | Moderate |
| Specificity | Low-Moderate |
| Associated Diseases | ALZHEIMER'S DISEASE, Dopaminergic Neuron Loss, Frontotemporal Dementia, LOCOMOTOR_DYSFUNCTION |
| Known Drugs/Compounds | curcumin, resveratrol, dimethyl fumarate, CR2_CRRY |
| Interactions | C1Q, IL6, STAT3, TFEB, CXCL10, HMGB1 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| KG Connections | 597 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |