biomarker 2,458 words KG: CX3CL1 2026-03-24
kind:biomarkersection:biomarkersstate:publishedevidence:strong
Contents

Fractalkine (CX3CL1) - Neuroinflammation Biomarker

🔬 Protein Info
Gene SymbolCX3CL1
Full NameFractalkine (C-X3-C Motif Chemokine Ligand 1)
AliasesC-X3-C Motif Chemokine Ligand 1
Chromosome16q13
Primary ExpressionNeurons (cortex, hippocampus), Endothelial cells, Dendritic cells
Amino Acids373 aa
PathwaysNeuroinflammatory
UniProt IDP78423
NCBI Gene ID6376
Ensembl IDENSG00000006210
OMIM601880
GeneCardsCX3CL1
Human Protein AtlasCX3CL1
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
InteractionsVIM, BDNF, FGF23, FNDC5, CX3CR1, SIRT1
KG Connections449 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (26)

Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.38
TREM2-Dependent Microglial Senescence Transition
Score: 0.74
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.65
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.57

Related Analyses (10)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (10)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
s:** - GPR32 knockout in microglia should worsen neuroinflam
falsification · proposed · Score: 0.40

Knowledge Graph (12 edges)

CX3CL1 mediates CX3CR1
CX3CL1 activates NEURODEGENERATION
CX3CL1 expressed_in OVERVIEW
CX3CL1 associated_with CXCR1
CX3CL1 activates VIM
CX3CL1 activates BDNF
CX3CL1 biomarker_for TGM2
CX3CL1 biomarker_for GPNMB
CX3CL1 biomarker_for HMGB1
CX3CL1 activates FGF23