gene 1,391 words KG: CX3CL1 2026-03-24
kind:genesection:genesstate:published
Contents

CX3CL1 — Fractalkine (C-X3-C Motif Chemokine Ligand 1)

🧬 Gene Info
Gene SymbolCX3CL1
Full NameFractalkine (C-X3-C Motif Chemokine Ligand 1)
AliasesC-X3-C Motif Chemokine Ligand 1
Chromosome16q13
Primary ExpressionNeurons (cortex, hippocampus), Endothelial cells, Dendritic cells
Amino Acids373 aa
PathwaysNeuroinflammatory
UniProt IDP78423
NCBI Gene ID6376
Ensembl IDENSG00000006210
OMIM601880
GeneCardsCX3CL1
Human Protein AtlasCX3CL1
Symbol [@limatola2014] CX3CL1 [@lee2010] [@bhaskar2010] [@morganti2012] Full Name [@cardona2006a] C-X3-C Motif Chemokine Ligand 1 (Fractalkine / Neurotactin) Chromosome16q13
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
InteractionsVIM, BDNF, FGF23, FNDC5, CX3CR1, SIRT1
KG Connections449 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (19)

Synaptic Pruning Precision Therapy
Score: 0.47
Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
TREM2-Dependent Microglial Senescence Transition
Score: 0.69

Related Analyses (7)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (2)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
ALS Therapeutic Landscape — Programs by Phase and Modal
disease · Pages share 3 hypotheses

Knowledge Graph (12 edges)

CX3CL1 mediates CX3CR1
CX3CL1 activates NEURODEGENERATION
CX3CL1 expressed_in OVERVIEW
CX3CL1 associated_with CXCR1
CX3CL1 activates VIM
CX3CL1 activates BDNF
CX3CL1 biomarker_for TGM2
CX3CL1 biomarker_for GPNMB
CX3CL1 biomarker_for HMGB1
CX3CL1 activates FGF23