gene 2,967 words KG: PLAU 2026-03-24
kind:genesection:genesstate:published
Contents

PLAU Gene (Urokinase)

🧬 Gene Info
Gene SymbolPLAU
AliasesuPA, urokinase, ATF
Chromosome10q22.2
Protein TypeProtease
Functionis a gene encoding a secreted serine protease that plays critical roles in fibrinolysis, extracellular matrix (ECM) remodeling, and cell migration.
Molecular Weight~54 kDa (pro-enzyme)
Amino Acids411 aa
Exons11
PathwaysTGF-β
UniProt IDP00750
NCBI Gene ID5328
GeneCardsPLAU
Human Protein AtlasPLAU
Gene NameUrokinase-type plasminogen activator
Entrez Gene ID5328
Associated DiseasesAls, Alzheimer, Leukemia, Ms
InteractionsCXCL10, CX3CL1, VIM, BDNF, FGF23, FGF21
KG Connections175 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (19)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (12)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (14)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: biomarker_for
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: biomarker_for

Knowledge Graph (12 edges)

PLAU activates PROGRANULIN
PLAU activates CXCL10
PLAU biomarker_for C1Q
PLAU activates CX3CL1
PLAU activates VIM
PLAU activates BDNF
PLAU biomarker_for TGM2
PLAU biomarker_for GPNMB
PLAU biomarker_for HMGB1
PLAU activates FGF23