| Gene Symbol | CALB2 |
| Chromosome | 16q22.2 [@wong2025] |
| Protein Type | Gene |
| Function | CALB2 encodes calretinin, a calcium-binding protein of the EF-hand family. |
| Primary Expression | specific neuronal populations and is considered a neuroprotective molecule due to its calcium-buffering capacity |
| Pathways | Mapk |
| UniProt ID | P22676 |
| NCBI Gene ID | 794 |
| Ensembl ID | ENSG00000171331 |
| GeneCards | CALB2 |
| Human Protein Atlas | CALB2 |
| CALB1 | Calbindin-D28k, a related calcium-binding protein with broader expression |
| CALB3 | Calbindin-related protein with similar EF-hand structure |
| PVALB | Parvalbumin, another calcium-binding protein in interneurons |
| GABAergic interneurons | Primary neuronal population expressing CALB2 |
| Associated Diseases | Huntington, neurodegeneration |
| Interactions | ASTROCYTES, Bdnf, BDNF, CALB1, CHRNA6, CREB1 |
| KG Connections | 70 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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