gene 704 words KG: EGR1 2026-03-24
kind:genesection:genesstate:published
Contents

EGR1 Gene

🧬 Gene Info
Gene SymbolEGR1
Full NameEarly Growth Response 1
AliasesEarly Growth Response protein 1
Chromosome5q31
Protein TypeTranscription Factor
FunctionEGR1 is an immediate-early transcription factor that regulates neuronal plasticity, learning, memory, and response to neural activity.
Molecular Weight59.8 kDa
PathwaysMAPK
UniProt IDP18146
NCBI Gene ID1958
Ensembl IDENSG00000120738
OMIM129500
GeneCardsEGR1
Human Protein AtlasEGR1
Associated DiseasesAD, ALI, ALS, ARM, Alzheimer
Known Drugs/Compoundsmetformin
InteractionsHNRNPK, NDP52, HNRNPA1, IGF1, FGF2, IGF1R
KG Connections421 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.41
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.36
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Molecular docking validation of ginger-PRMT1 interactions
exploratory · proposed · Score: 0.80

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates
ATF3 Gene
gene · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates

Knowledge Graph (12 edges)

EGR1 regulates PRMT1
EGR1 interacts_with IGF1R
EGR1 interacts_with PI3K
EGR1 activates HNRNPK
EGR1 activates NDP52
EGR1 activates HNRNPA1
EGR1 activates IGF1
EGR1 participates_in cardiac hypertrophy
EGR1 activates FGF2
EGR1 associated_with PRMT1