| Gene Symbol | CDK6 |
| Aliases | Cyclin-Dependent Kinase 6 |
| Protein Type | Serine/Threonine Kinase |
| Function | The CDK6 gene encodes Cyclin-Dependent Kinase 6, a 326-amino acid serine/threonine kinase |
| Primary Expression | gliomas, lymphomas, and carcinomas |
| Molecular Weight | 37 kDa |
| Amino Acids | 326 aa |
| Ensembl ID | ENSG00000105810 |
| GeneCards | CDK6 |
| Human Protein Atlas | CDK6 |
| Cell Cycle G1/S Transition | Phosphorylates retinoblastoma protein (Rb), releasing E2F transcription factors to activate S-phase genes[@lim2013]. |
| Cellular Differentiation | Regulates differentiation of various cell types including neurons, osteoblasts, and adipocytes. |
| Transcriptional Regulation | Controls gene expression through phosphorylation of transcription factors and chromatin modifiers. |
| DNA Damage Response | Involved in DNA damage checkpoints and repair. |
| Synaptic Plasticity | Regulates synaptic protein synthesis and dendritic spine morphology. |
| Associated Diseases | Als, Cancer, Carcinoma, Tumor |
| Interactions | AKT, AMBRA1, AND, AUTOPHAGY, AUTOPHAGY-RELATED GENES, CANCER |
| KG Connections | 74 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!